Sandia National Laboratories, Albuquerque, New Mexico, 87185, USA; Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, NC, 27695-7115, USA.
Adv Healthc Mater. 2014 Jun;3(6):876-81. doi: 10.1002/adhm.201300541. Epub 2013 Dec 21.
The determination of electrolytes is invaluable for point of care diagnostic applications. An ion selective transdermal microneedle sensor is demonstrated for potassium by integrating a hollow microneedle with a microfluidic chip to extract fluid through a channel towards a downstream solid-state ion-selective-electrode (ISE). 3D porous carbon and 3D porous graphene electrodes, made via interference lithography, are compared as solid-state transducers for ISE's and evaluated for electrochemical performance, stability, and selectivity. The porous carbon K(+) ISE's show better performance than the porous graphene K(+) ISE's, capable of measuring potassium across normal physiological concentrations in the presence of interfering ions with greater stability. This new microfluidic/microneedle platform shows promise for medical applications.
电解质的测定对于即时诊断应用非常重要。通过将中空微针与微流控芯片集成，设计了一种用于钾离子的离子选择性经皮微针传感器，通过通道将液体提取到下游固态离子选择性电极（ISE）。通过干涉光刻法制造的 3D 多孔碳和 3D 多孔石墨烯电极被用作 ISE 的固态换能器，并对其电化学性能、稳定性和选择性进行了评估。多孔碳 K(+)ISE 的性能优于多孔石墨烯 K(+)ISE，在存在干扰离子的情况下，能够在更大的稳定性下测量正常生理浓度范围内的钾离子。这种新的微流控/微针平台在医疗应用方面具有广阔的前景。
