Hwang Sang-Hyun, Ryu Hye-Jung, Kang Soo Jin, Yun E Hwa, Lim Min Kyung, Kim Heung Tae, Lee Jin Soo, Lee Do-Hoon
Department of Laboratory Medicine, Center for Diagnostic Oncology, National Cancer Center, Goyang, Republic of Korea E-mail :
Asian Pac J Cancer Prev. 2014 Jan;14(11):6591-3. doi: 10.7314/apjcp.2013.14.11.6591.
Environmental tobacco smoking (ETS) significantly contributes to morbidity and mortality and is a known risk factor for lung cancer development in lifelong nonsmokers. The metabolite 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (NNAL-Glucs) have now emerged as leading biomarkers for the study of carcinogen exposure in non-smokers exposed to ETS.
We carried out our study on NNAL in the urine of non-smokers exposed to ETS and the association between ETS and lung cancer. Subjects were enrolled from 2008-2010. NNAL was analyzed for 74 non-smoking lung cancer and 85 healthy controls. The main objective of this study was to provide an estimate of the risk of lung cancer from exposure to ETS in the Korean population.
The mean NNAL concentration in urine was significantly lower in non-smoking patient groups (n=74) than in control groups (n=85) (4.7±15.0 pg/mg, 6.5 ± 17.9 pg/mg, respectively, Mann-Whitney U test, p<0.001).
The urine NNAL of non-smoking patients with lung cancer was not elevated with regard to the non-smoking control group. This may be due to life-style changes after diagnosis. A prospective study will be needed to evaluate the association of NNAL and non-smoking lung cancer.
环境烟草烟雾（ETS）显著导致发病和死亡，并且是终生不吸烟者患肺癌的已知风险因素。代谢物4-（甲基亚硝胺基）-1-（3-吡啶基）-1-丁醇（NNAL）及其葡糖苷酸（NNAL-Glucs）现已成为研究接触ETS的非吸烟者致癌物暴露的主要生物标志物。
我们对接触ETS的非吸烟者尿液中的NNAL以及ETS与肺癌之间的关联进行了研究。研究对象于2008年至2010年招募。对74例非吸烟肺癌患者和85例健康对照者的NNAL进行了分析。本研究的主要目的是估计韩国人群接触ETS患肺癌的风险。
非吸烟患者组（n = 74）尿液中NNAL的平均浓度显著低于对照组（n = 85）（分别为4.7±15.0 pg/mg和6.5±17.9 pg/mg，曼-惠特尼U检验，p<0.001）。
与非吸烟对照组相比，非吸烟肺癌患者尿液中的NNAL没有升高。这可能是由于诊断后的生活方式改变。需要进行前瞻性研究来评估NNAL与非吸烟肺癌的关联。
