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1
VH gene family utilization is regulated by a locus outside of the VH region.VH基因家族的利用受VH区域之外的一个基因座调控。
J Exp Med. 1988 Apr 1;167(4):1499-504. doi: 10.1084/jem.167.4.1499.
2
Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice.新生或成年免疫球蛋白H链同基因小鼠外周B细胞库中VH基因家族的差异表达。
J Exp Med. 1992 Jun 1;175(6):1449-56. doi: 10.1084/jem.175.6.1449.
3
Regulation of VH-gene expression is a lineage-specific developmental marker.
Eur J Immunol. 1994 Jun;24(6):1353-8. doi: 10.1002/eji.1830240617.
4
Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells.重链和κ轻链可变基因家族的随机配对发生在多克隆激活的B细胞中。
Proc Natl Acad Sci U S A. 1990 Jul;87(13):4932-6. doi: 10.1073/pnas.87.13.4932.
5
Influence of the immunoglobulin heavy chain locus on expression of the VK1GAC light chain.免疫球蛋白重链基因座对VK1GAC轻链表达的影响。
J Immunol. 1984 Jul;133(1):465-70.
6
Developmentally regulated and strain-specific expression of murine VH gene families.小鼠VH基因家族的发育调控及品系特异性表达。
J Exp Med. 1988 Jul 1;168(1):417-35. doi: 10.1084/jem.168.1.417.
7
Selection of VH gene repertoires: differentiating B cells of adult bone marrow mimic fetal development.VH基因库的选择：成年骨髓中分化的B细胞模拟胎儿发育。
Int Immunol. 1990;2(1):15-23. doi: 10.1093/intimm/2.1.15.
8
Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice.通过原位杂交对B细胞集落进行基因分型分析。成年C57BL/6和BALB/c小鼠中三个VH家族的化学计量表达。
J Exp Med. 1987 Jul 1;166(1):163-72. doi: 10.1084/jem.166.1.163.
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Direct in vivo VH to JH rearrangement violating the 12/23 rule.体内直接发生的VH至JH重排违反了12/23规则。
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VH gene family expression in mice with the xid defect.xid缺陷小鼠中VH基因家族的表达
J Exp Med. 1991 Jul 1;174(1):45-51. doi: 10.1084/jem.174.1.45.

引用本文的文献

1
The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters.小鼠Igh-V基因座的组织。VH基因家族簇的分散、散布及进化。
J Exp Med. 1988 Dec 1;168(6):2261-78. doi: 10.1084/jem.168.6.2261.
2
Infrequent utilization of the immunoglobulin heavy chain variable region(s) identical or closely related to that of MOPC315 myeloma protein in the functional V region formation in B-precursor cell lines.在B前体细胞系功能性V区形成过程中，与MOPC315骨髓瘤蛋白免疫球蛋白重链可变区相同或密切相关的可变区使用频率较低。
Immunology. 1989 Dec;68(4):453-7.
3
Molecular cloning of the primary IgH repertoire: a quantitative analysis of VH gene usage in adult mice.原发性免疫球蛋白重链基因库的分子克隆：成年小鼠中VH基因使用情况的定量分析
EMBO J. 1989 Aug;8(8):2313-20. doi: 10.1002/j.1460-2075.1989.tb08358.x.
4
Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.JH近端VH基因的偏向性表达出现在新生小鼠和成年小鼠新产生的抗体库中。
J Exp Med. 1990 Mar 1;171(3):843-59. doi: 10.1084/jem.171.3.843.
5
The physical organization of the human immunoglobulin heavy chain gene complex.人类免疫球蛋白重链基因复合体的物理组织
EMBO J. 1990 Oct;9(10):3303-13. doi: 10.1002/j.1460-2075.1990.tb07530.x.
6
Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region.艾丽西亚兔免疫球蛋白重链可变区（VH）基因的表型表达改变可能反映了最靠近连接区的VH基因存在小的缺失。
Proc Natl Acad Sci U S A. 1990 Jul;87(14):5444-8. doi: 10.1073/pnas.87.14.5444.
7
The genomic organization of immunoglobulin VH genes in Xenopus laevis shows evidence for interspersion of families.非洲爪蟾免疫球蛋白VH基因的基因组组织显示出基因家族散布的证据。
Nucleic Acids Res. 1991 Jun 11;19(11):3061-6. doi: 10.1093/nar/19.11.3061.
8
Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires.正常血清免疫球蛋白参与外周B细胞库的选择。
Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5640-4. doi: 10.1073/pnas.88.13.5640.
9
A deletion map of the human immunoglobulin heavy chain variable region.人类免疫球蛋白重链可变区的缺失图谱。
J Exp Med. 1991 Aug 1;174(2):335-49. doi: 10.1084/jem.174.2.335.
10
Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice.新生或成年免疫球蛋白H链同基因小鼠外周B细胞库中VH基因家族的差异表达。
J Exp Med. 1992 Jun 1;175(6):1449-56. doi: 10.1084/jem.175.6.1449.

本文引用的文献

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Somatic generation of antibody diversity.抗体多样性的体细胞产生。
Nature. 1983 Apr 14;302(5909):575-81. doi: 10.1038/302575a0.
2
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines.前B细胞系中最靠近连接区（JH）的重链可变区（VH）基因片段的优先利用。
Nature. 1984;311(5988):727-33. doi: 10.1038/311727a0.
3
The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes.小鼠中的免疫球蛋白重链可变区（Igh-V）基因座。I. 一百个Igh-V基因构成七个同源基因家族。
Eur J Immunol. 1984 Oct;14(10):922-30. doi: 10.1002/eji.1830141012.
4
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals.前B细胞中的染色体外DNA底物在免疫球蛋白V-(D)-J连接信号处发生倒位或缺失。
Cell. 1987 Jun 19;49(6):775-83. doi: 10.1016/0092-8674(87)90615-5.
5
Organization of the murine immunoglobulin VH complex in the inbred strains.近交系小鼠免疫球蛋白VH复合体的组织架构
EMBO J. 1987 Oct;6(10):2931-7. doi: 10.1002/j.1460-2075.1987.tb02597.x.
6
Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice.通过原位杂交对B细胞集落进行基因分型分析。成年C57BL/6和BALB/c小鼠中三个VH家族的化学计量表达。
J Exp Med. 1987 Jul 1;166(1):163-72. doi: 10.1084/jem.166.1.163.
7
One heavy chain variable region gene segment subfamily in the BALB/c mouse contains 500-1000 or more members.BALB/c小鼠中的一个重链可变区基因片段亚家族包含500 - 1000个或更多成员。
Cell. 1986 Nov 7;47(3):461-70. doi: 10.1016/0092-8674(86)90603-3.
8
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments.未重排VH基因片段的发育控制及组织特异性表达。
Cell. 1985 Feb;40(2):271-81. doi: 10.1016/0092-8674(85)90141-2.
9
VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay.通过RNA集落印迹分析检测B细胞和前B细胞来源的集落中VH基因家族的利用情况。
EMBO J. 1986 Dec 20;5(13):3475-81. doi: 10.1002/j.1460-2075.1986.tb04672.x.
10
Detection of RNA transcripts in normal lymphoid and myeloid colonies.
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VH基因家族的利用受VH区域之外的一个基因座调控。

VH gene family utilization is regulated by a locus outside of the VH region.

作者信息

Wu G E, Paige C J

机构信息

Basel Institute for Immunology, Switzerland.

出版信息

J Exp Med. 1988 Apr 1;167(4):1499-504. doi: 10.1084/jem.167.4.1499.

DOI:10.1084/jem.167.4.1499
PMID:2451707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188925/
Abstract

We have used the RNA colony blot method to examine VH usage in colonies derived from primary splenic B cells. We found that there are strain-specific differences in the pattern of VH usage. Using parental F1, congenic, and recombinant inbred strains we demonstrate that the genetic element that causes the observed phenotype is: (a) stably expressed; (b) not due to maternal influence; (c) not due to dominate diffusible factors; (d) not linked to cloning efficiency; and (e) outside the Igh locus.

摘要

我们使用RNA集落印迹法检测了源自原代脾B细胞的集落中的VH使用情况。我们发现VH使用模式存在品系特异性差异。利用亲代F1、同源近交系和重组近交系，我们证明导致观察到的表型的遗传元件具有以下特点：(a)稳定表达；(b)非母源影响所致；(c)非显性可扩散因子所致；(d)与克隆效率无关；(e)位于Igh基因座之外。