Morales J A, Herzog S, Kompter C, Frese K, Rott R
Institut für Veterinär-Pathologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.
Med Microbiol Immunol. 1988;177(2):51-68. doi: 10.1007/BF00189527.
In this study it has been shown that infection of mother rats by Borna disease virus (BDV) from infected newborns led to a fatal disease. This differed both in clinical symptoms and in histological alterations from the form of the disease which occurred after intracerebral (i.c.) infection. Both parameters were, however, similar to those seen after experimental intranasal (i.n.) infection of adult rats. Detailed immunohistological studies showed clearly that after experimental i.n. infection, the infecting virus migrates intraaxonally from the neuroreceptors in the olfactory epithelium into the brain. It is therefore suggested that i.n. transmission is an important route of natural BDV infection.
在本研究中已表明，感染的新生鼠的博尔纳病病毒（BDV）感染母鼠会导致一种致命疾病。这种疾病在临床症状和组织学改变方面均与脑内（i.c.）感染后出现的疾病形式不同。然而，这两个参数与成年大鼠实验性鼻内（i.n.）感染后所见的参数相似。详细的免疫组织学研究清楚地表明，在实验性i.n.感染后，感染病毒从嗅上皮中的神经感受器沿轴突内迁移至脑内。因此，提示鼻内传播是BDV自然感染的重要途径。
