Fabris Larissa Rodrigues, Andrade Úrsulla Vilella, Ferreira Dos Santos Aline, Marques Ana Paula da Costa, Oliveira Sandra Maria do Valle Leone de, Mendes Rinaldo Pôncio, Paniago Anamaria Mello Miranda
Faculdade de Medicina, Universidade Federal de Mato Grosso do Sul (UFMS), Campo GrandeMS, Brazil, Faculdade de Medicina, Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil. E-mails:
Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, Campo Grande (UFMS)MS, Brazil, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, Campo Grande (UFMS), MS, Brazil. E-mail:
Rev Inst Med Trop Sao Paulo. 2014 Mar-Apr;56(2):121-5. doi: 10.1590/S0036-46652014000200006.
With the objective to evaluate the behavior of paracoccidioidomycosis in the last three decades, clinical and epidemiological data of 595 patients admitted to clinical services of the Federal University of Mato Grosso do Sul from 1980 to 2009 were investigated. Gender, age distribution, clinical form, comorbidity with tuberculosis or AIDS, and mortality were compared by decades of clinical admission. It was shown that during the three decades there was a decrease in women percentage, and the same manner occurred a reduction in participants in the age group of 20 to 39 years. Moreover, the acute/subacute forms have been diminished in the period. These fluctuations are closely related and can be simultaneously analyzed. Increased AIDS co-infection prevalence from the first to the second decade was also revealed, coinciding with the appearance of the retroviral epidemic and stabilizing during the third decade. No change in the tuberculosis co-infection rate was observed (overall = 6.9%). It reinforces the importance of this co-morbidity. The overall mortality rate remained steady at 6.7%, not varying significantly from one decade to another. The persistent mortality rate calls attention to the importance of this neglected disease.
为评估过去三十年副球孢子菌病的发病情况，我们调查了1980年至2009年期间在南马托格罗索联邦大学临床科室住院的595例患者的临床和流行病学数据。按临床入院年代比较了性别、年龄分布、临床类型、合并结核病或艾滋病情况以及死亡率。结果显示，在这三十年中，女性比例下降，20至39岁年龄组的参与者也减少。此外，在此期间急性/亚急性形式有所减少。这些波动密切相关，可以同时进行分析。还发现从第一个十年到第二个十年艾滋病合并感染患病率增加，这与逆转录病毒流行的出现相吻合，并在第三个十年稳定下来。未观察到结核病合并感染率的变化（总体为6.9%）。这强化了这种合并症的重要性。总体死亡率稳定在6.7%，十年间无显著变化。持续的死亡率凸显了这种被忽视疾病的重要性。
