对从日本分离出的一株耐多药大肠杆菌中金属β-内酰胺酶NDM-3的生化分析。
Biochemical analysis of metallo-β-lactamase NDM-3 from a multidrug-resistant Escherichia coli strain isolated in Japan.
作者信息
Tada Tatsuya, Miyoshi-Akiyama Tohru, Shimada Kayo, Kirikae Teruo
机构信息
Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan.
Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan
出版信息
Antimicrob Agents Chemother. 2014 Jun;58(6):3538-40. doi: 10.1128/AAC.02793-13. Epub 2014 Mar 31.
Abstract
New Delhi metallo-β-lactamase-3 (NDM-3) was identified in a multidrug-resistant Escherichia coli isolate, NCGM77, obtained from the feces of a patient in Japan. The enzymatic activities of NDM-3 against β-lactams were similar to those of NDM-1, although NDM-3 showed slightly lower kcat/Km ratios for all the β-lactams tested except for doripenem. The genetic context for blaNDM-3 was tnpA-blaNDM-3-bleMBL-trpF-dsbC-tnpA-sulI-qacEdeltaI-aadA2-dfrA1, which was present on an approximately 250-kb plasmid.
摘要
在从一名日本患者粪便中分离出的多重耐药性大肠杆菌菌株NCGM77中鉴定出了新德里金属β-内酰胺酶-3（NDM-3）。NDM-3对β-内酰胺类药物的酶活性与NDM-1相似，不过除多黏菌素外，NDM-3对所有测试的β-内酰胺类药物的催化常数与米氏常数之比略低。blaNDM-3的基因背景为tnpA-blaNDM-3-bleMBL-trpF-dsbC-tnpA-sulI-qacEdeltaI-aadA2-dfrA1，该基因背景存在于一个约250kb的质粒上。
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