Amstadter Ananda B, Myers John M, Kendler Kenneth S
Ananda B. Amstadter, PhD, John M. Myers, MS, Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia; Kenneth S. Kendler, MD, Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, and Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Br J Psychiatry. 2014 Oct;205(4):275-80. doi: 10.1192/bjp.bp.113.130906. Epub 2014 Apr 10.
The source of variability in people's response to stressful life events is poorly understood.
We examine the genetic and environmental underpinning of resilience (i.e. the difference between the twins' internalising symptoms and their predicted symptoms based on cumulative stressful life events).
Stressful life event exposure and internalising symptoms were assessed at two time points in 7500 adult twins. Using the residual between actual and predicted internalising symptom total score, twin modelling was conducted for each wave separately and longitudinally.
Resilience was found to have a moderate genetic heritability at each wave (31%). Qualitative gender effects were found. Incorporating error of measurement into the model increased the estimated heritability for the latent construct of resilience (50%). When measurement error and occasion-specific effects were removed, environmental influences contributed roughly equally to level of resilience.
Both genes and environment influence level of psychiatric resilience, and are largely stable over time. Environmental influences can have an enduring effect on resilience.
人们对应激性生活事件的反应差异来源尚不清楚。
我们研究复原力的遗传和环境基础（即双胞胎的内化症状与其基于累积应激性生活事件预测的症状之间的差异）。
在7500对成年双胞胎的两个时间点评估应激性生活事件暴露情况和内化症状。利用实际内化症状总分与预测内化症状总分之间的残差，分别对每个时间点进行双胞胎建模，并进行纵向分析。
发现复原力在每个时间点都有中等程度的遗传遗传性（约31%）。发现了定性的性别效应。将测量误差纳入模型增加了复原力潜在结构的估计遗传性（约50%）。当去除测量误差和特定时间效应时，环境影响对复原力水平的贡献大致相等。
基因和环境都影响心理复原力水平，且随时间基本稳定。环境影响可对复原力产生持久作用。
