蜂窝酸，一种来自斯里兰卡特有的一种兰花真菌内生菌的抗菌三萜类化合物。
Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, sp. of orchid endemic to Sri Lanka.
作者信息
Ratnaweera Pamoda B, Williams David E, de Silva E Dilip, Wijesundera Ravi L C, Dalisay Doralyn S, Andersen Raymond J
机构信息
Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka ; Department of Science and Technology, Uva Wellassa University, Badulla, Sri Lanka.
Department of Chemistry and Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada.
出版信息
Mycology. 2014 Mar;5(1):23-28. doi: 10.1080/21501203.2014.892905. Epub 2014 Mar 25.
An endophytic fungus was isolated from surface sterilized leaf segments of an orchid endemic to Sri Lanka, and was identified as sp. by morphological characters and DNA sequencing. Bioassay-guided chromatographic fractionation of the organic extract of a laboratory culture of this fungus led to the isolation of the known antibacterial helvolic acid. Helvolic acid was active against the Gram-positive bacteria, [minimal inhibitory concentrations (MIC), 2 μg mL] and methicillin-resistant (MIC, 4 μg mL).
从斯里兰卡特有的一种兰花经表面消毒的叶片切段中分离出一种内生真菌，并通过形态特征和DNA测序将其鉴定为sp.。对该真菌实验室培养物的有机提取物进行生物测定导向的色谱分离，得到了已知的抗菌蠕孢酸。蠕孢酸对革兰氏阳性菌有活性，[最低抑菌浓度（MIC），2μg/mL]，对耐甲氧西林菌有活性（MIC，4μg/mL）。
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