Arble Deanna M, Bass Joseph, Behn Cecilia Diniz, Butler Matthew P, Challet Etienne, Czeisler Charles, Depner Christopher M, Elmquist Joel, Franken Paul, Grandner Michael A, Hanlon Erin C, Keene Alex C, Joyner Michael J, Karatsoreos Ilia, Kern Philip A, Klein Samuel, Morris Christopher J, Pack Allan I, Panda Satchidananda, Ptacek Louis J, Punjabi Naresh M, Sassone-Corsi Paolo, Scheer Frank A, Saxena Richa, Seaquest Elizabeth R, Thimgan Matthew S, Van Cauter Eve, Wright Kenneth P
Department of Surgery, University of Michigan, Ann Arbor, MI.
Department of Medicine, Endocrinology Division, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Sleep. 2015 Dec 1;38(12):1849-60. doi: 10.5665/sleep.5226.
A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice.
美国国立糖尿病、消化和肾脏疾病研究所举办了一次研讨会，重点关注睡眠和昼夜节律紊乱对能量平衡及糖尿病的影响。该研讨会确定了该领域研究的若干关键原则和一些具体机会。睡眠/昼夜节律研究领域的研究人员与新陈代谢/糖尿病领域的研究人员之间的积极合作将推动该领域的研究。有必要将基础研究的精妙发现转化为改善美国公众的代谢健康。此外，研究睡眠/昼夜节律紊乱对人类影响的研究人员需要超越胰岛素和葡萄糖的测量，进行更深入的表型分析。还需要将睡眠和昼夜节律评估以及睡眠呼吸障碍评估纳入所有正在进行的与糖尿病风险相关的队列研究中。人体研究需要以一般人群中患有这些疾病的受试者的研究来补充基于实验室的短期人体模拟短睡眠和轮班工作等研究。可以想象会发生慢性适应，如果是这样，就需要确定并理解其发生的机制。准备好进行转化的特定机会领域包括研究对糖尿病前期和阻塞性睡眠呼吸暂停（OSA）患者进行持续气道正压通气（CPAP）治疗是否能预防或延缓糖尿病的发生，以及限时进食对人类肥胖率的影响是否与对小鼠的影响相同。
