氧化铜和氧化铁纳米颗粒抗多药耐药生物膜形成尿路病原体的抗菌生物膜活性比较研究。
Comparative study of antibiofilm activity of copper oxide and iron oxide nanoparticles against multidrug resistant biofilm forming uropathogens.
机构信息
Centre for Studies in Biotechnology, Dibrugarh University, Dibrugarh, 786004 Assam India.
Guwahati Biotech Park, Technology Complex, IIT-Guwahati, Guwahati, 781039 Assam India.
出版信息
Indian J Microbiol. 2014 Sep;54(3):365-8. doi: 10.1007/s12088-014-0462-z. Epub 2014 Mar 12.
Abstract
The effectiveness of the metal oxide nanoparticles viz. CuO and Fe2O3 as antibacterial agents against multidrug resistant biofilm forming bacteria was evaluated. CuO nanoparticles were also experimented for antibiofilm and time kill assay. The CuO displayed maximum antibacterial activity with zone of inhibition of (22 ± 1) mm against methicillin resistant Staphylococcus aureus (MRSA) followed by Escherichia coli (18 ± 1) mm. The Fe2O3 showed the zone of inhibition against MRSA of (14 ± 1) mm followed by E. coli (12 ± 1) mm. CuO proved to be more toxic than Fe2O3 nanoparticles showing significantly high antibacterial activity and found to possess dose dependent antibiofilm properties.
摘要
评估了金属氧化物纳米粒子（如 CuO 和 Fe2O3）作为抗菌剂对抗多药耐药生物膜形成细菌的效果。还对 CuO 纳米粒子进行了抗生物膜和时间杀伤试验。CuO 显示出最大的抗菌活性，对耐甲氧西林金黄色葡萄球菌（MRSA）的抑菌圈为（22±1）mm，其次是大肠杆菌（18±1）mm。Fe2O3 对 MRSA 的抑菌圈为（14±1）mm，其次是大肠杆菌（12±1）mm。CuO 比 Fe2O3 纳米粒子更具毒性，表现出更高的抗菌活性，并且具有剂量依赖性的抗生物膜特性。
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