改善工业微生物的功能注释：以巴斯德毕赤酵母为例的案例研究
Improving functional annotation for industrial microbes: a case study with Pichia pastoris.
作者信息
Dikicioglu Duygu, Wood Valerie, Rutherford Kim M, McDowall Mark D, Oliver Stephen G
机构信息
Cambridge Systems Biology Centre & Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
出版信息
Trends Biotechnol. 2014 Aug;32(8):396-9. doi: 10.1016/j.tibtech.2014.05.003. Epub 2014 Jun 11.
Abstract
The research communities studying microbial model organisms, such as Escherichia coli or Saccharomyces cerevisiae, are well served by model organism databases that have extensive functional annotation. However, this is not true of many industrial microbes that are used widely in biotechnology. In this Opinion piece, we use Pichia (Komagataella) pastoris to illustrate the limitations of the available annotation. We consider the resources that can be implemented in the short term both to improve Gene Ontology (GO) annotation coverage based on annotation transfer, and to establish curation pipelines for the literature corpus of this organism.
摘要
研究诸如大肠杆菌或酿酒酵母等微生物模式生物的科研群体，受益于具有广泛功能注释的模式生物数据库。然而，许多在生物技术中广泛应用的工业微生物却并非如此。在这篇观点文章中，我们以巴斯德毕赤酵母为例来说明现有注释的局限性。我们考虑了在短期内可以实施的资源，以便基于注释转移来提高基因本体论（GO）注释覆盖率，并为该生物的文献语料库建立注释流程。
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