健康衰老与疾病中的B细胞功能及流感疫苗反应
B cell function and influenza vaccine responses in healthy aging and disease.
作者信息
Frasca Daniela, Blomberg Bonnie B
机构信息
University of Miami Miller School of Medicine, Miami, FL 33136, USA.
University of Miami Miller School of Medicine, Miami, FL 33136, USA.
出版信息
Curr Opin Immunol. 2014 Aug;29:112-8. doi: 10.1016/j.coi.2014.05.008. Epub 2014 Jun 14.
Abstract
Influenza vaccination is less effective in elderly as compared to young individuals. Several studies have addressed the identification of immune biomarkers able to monitor or predict a protective humoral immune response to the vaccine. In this review, we summarize these data, with emphasis on the effects of aging on influenza vaccine-specific B cell responses in healthy individuals and patients with Type-2 Diabetes, HIV and cardiovascular diseases.
摘要
与年轻人相比，流感疫苗在老年人中的效果较差。多项研究致力于确定能够监测或预测对疫苗产生保护性体液免疫反应的免疫生物标志物。在本综述中，我们总结了这些数据，重点关注衰老对健康个体以及2型糖尿病、HIV和心血管疾病患者流感疫苗特异性B细胞反应的影响。
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