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Molecular dynamics simulations elucidate the mechanism of proton transport in the glutamate transporter EAAT3.分子动力学模拟阐明了谷氨酸转运体EAAT3中质子转运的机制。
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The conserved histidine 295 does not contribute to proton cotransport by the glutamate transporter EAAC1.保守的组氨酸295对谷氨酸转运体EAAC1的质子共转运没有作用。
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Elucidation of the Role of a Conserved Methionine in Glutamate Transporters and Its Implication for Force Fields.阐明谷氨酸转运体中一个保守蛋氨酸残基的作用及其对力场的影响。
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Low Affinity and Slow Na+ Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter GltPh.在二级主动转运蛋白GltPh中,低亲和力和缓慢的钠离子结合先于高亲和力的天冬氨酸结合。
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Role of protein matrix rigidity and local polarization effects in the monovalent cation selectivity of crystallographic sites in the Na-coupled aspartate transporter Glt(Ph).蛋白基质硬度和局部极化效应对 Na 偶联天冬氨酸转运体 Glt(Ph)中晶体位点单价阳离子选择性的作用。
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The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter.谷氨酸转运体的双重特性:氯离子通道与转运体
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Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.谷氨酸转运体转运循环中离子结合与结构转变的耦合
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1
Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters.在谷氨酸转运体中,底物转运和阴离子渗透通过不同的途径进行。
Elife. 2017 Jun 1;6:e25850. doi: 10.7554/eLife.25850.
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Computational Studies of Glutamate Transporters.谷氨酸转运体的计算研究
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本文引用的文献

1
Molecular dynamics simulations elucidate the mechanism of proton transport in the glutamate transporter EAAT3.分子动力学模拟阐明了谷氨酸转运体EAAT3中质子转运的机制。
Biophys J. 2014 Jun 17;106(12):2675-83. doi: 10.1016/j.bpj.2014.05.010.
2
Crystal structure of a substrate-free aspartate transporter.无底物天冬氨酸转运蛋白的晶体结构。
Nat Struct Mol Biol. 2013 Oct;20(10):1224-6. doi: 10.1038/nsmb.2663. Epub 2013 Sep 8.
3
Intracellular gating in an inward-facing state of aspartate transporter Glt(Ph) is regulated by the movements of the helical hairpin HP2.天冬氨酸转运体 Glt(Ph) 内向构象的胞内门控由螺旋发夹 HP2 的运动调节。
J Biol Chem. 2013 Mar 22;288(12):8231-8237. doi: 10.1074/jbc.M112.438432. Epub 2013 Feb 5.
4
Protonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1.参与谷氨酸转运体 EAAC1 与 Na(+) 结合的保守酸性氨基酸的质子化状态。
ACS Chem Neurosci. 2012 Dec 19;3(12):1073-83. doi: 10.1021/cn300163p. Epub 2012 Oct 19.
5
Molecular dynamics investigation of Cl- and water transport through a eukaryotic CLC transporter.通过真核 CLC 转运蛋白对 Cl-和水的传输进行分子动力学研究。
Biophys J. 2012 Mar 21;102(6):1363-71. doi: 10.1016/j.bpj.2012.01.056. Epub 2012 Mar 20.
6
Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh.膜的限制选择性地指导谷氨酸转运蛋白 GltPh 的交替访问动力学。
Biophys J. 2012 Mar 21;102(6):1331-40. doi: 10.1016/j.bpj.2012.02.028. Epub 2012 Mar 20.
7
Protonation of glutamate 208 induces the release of agmatine in an outward-facing conformation of an arginine/agmatine antiporter.谷氨酸 208 的质子化诱导胍丁胺从精氨酸/胍丁胺反向转运体的外向构象中释放。
J Biol Chem. 2011 Jun 3;286(22):19693-701. doi: 10.1074/jbc.M110.202085. Epub 2011 Apr 12.
8
Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter.鉴定谷氨酸转运体中的第三个 Na+ 结合位点和细胞外结合事件的序列。
Biophys J. 2010 Sep 8;99(5):1416-25. doi: 10.1016/j.bpj.2010.06.052.
9
Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model.谷氨酸转运体中第三个钠离子结合位点的证据表明存在离子/底物偶联模型。
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13912-7. doi: 10.1073/pnas.1006289107. Epub 2010 Jul 15.
10
Na(+):aspartate coupling stoichiometry in the glutamate transporter homologue Glt(Ph).Na(+):谷氨酸转运体同源物 Glt(Ph)中的天冬氨酸偶联计量比。
Biochemistry. 2010 May 4;49(17):3511-3. doi: 10.1021/bi100430s.

Coupling between neurotransmitter translocation and protonation state of a titratable residue during Na ⁺-coupled transport.

作者信息

Bahar Ivet

机构信息

Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

出版信息

Biophys J. 2014 Jun 17;106(12):2547-8. doi: 10.1016/j.bpj.2014.05.011.

DOI:10.1016/j.bpj.2014.05.011
PMID:24940770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4070272/
Abstract
摘要