Yanfang Ren, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
Huiling Wang, Department of Obstetrics & Gynecology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
Pak J Med Sci. 2014 May;30(3):634-7. doi: 10.12669/pjms.303.4558.
This study was conducted was to detect vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) syndrome and to investigate VEGF correlation with PIH occurrence.
Double-antibody enzyme-linked immunosorbent assay and fluorescent quantitative polymerase chain reaction were used to detect VEGF levels in the peripheral blood of non-pregnant women (normal group, 30 cases), normal pregnant women (pregnancy group, 30 cases) and PIH patients (PIH group, 30 cases).
VEGF level in the pregnancy group was significantly higher than in the normal group, and the difference between these two groups was significant (P < 0.001). In the pregnancy group, VEGF reached the maximum level at the metaphase stage of pregnancy and started to decrease at advanced pregnancy. VEGF level in the PIH group was significantly lower than in the pregnancy group at advanced pregnancy (P < 0.01), and VEGF level significantly and gradually decreased with PIH aggravation (P < 0.05).
The significant decrease of VEGF level after pregnancy was possibly an important factor of PIH pathogenesis.
本研究旨在检测妊娠高血压综合征（PIH）患者外周血中血管内皮生长因子（VEGF）水平，并探讨 VEGF 与 PIH 发生的相关性。
采用双抗体酶联免疫吸附法和荧光定量聚合酶链反应检测非孕妇（正常组，30 例）、正常孕妇（妊娠组，30 例）和 PIH 患者（PIH 组，30 例）外周血 VEGF 水平。
妊娠组 VEGF 水平明显高于正常组，两组比较差异有统计学意义（P<0.001）。妊娠组 VEGF 在妊娠中期达到最高水平，妊娠晚期开始下降。妊娠晚期 PIH 组 VEGF 水平明显低于妊娠组（P<0.01），且随着 PIH 加重 VEGF 水平呈显著逐渐下降（P<0.05）。
妊娠后 VEGF 水平显著下降可能是 PIH 发病机制的重要因素。
