Santiago M B, Cossermelli W, Tuma M F, Pinto M N, Oliveira R M
Department of Rheumatology, School of Medicine, University of São Paulo, Brazil.
Clin Rheumatol. 1989 Mar;8(1):23-8. doi: 10.1007/BF02031064.
IgG or IgM anticardiolipin antibodies were present in the sera of 67% of 33 patients with Hansen's disease, in 53% of 30 patients with tuberculosis and in 50% of 16 patients with endocarditis. Despite the high frequency of these antibodies, no patient had a history of thrombosis or abortion. Anti-denatured DNA antibodies were tested in patients with tuberculosis and patients with Hansen's disease. Only in the latter group did we observe a statistically significant association between anticardiolipin and anti-denatured DNA antibodies. Anticardiolipin binding activity, however, could not be inhibited by preincubation of sera with a variable concentration of denatured DNA. These data suggest that: a) Anticardiolipin antibodies in infectious diseases do not necessarily participate in the pathogenesis of thrombotic or obstetric complications; b) Anti-denatured DNA and anticardiolipin antibodies in the population studied do not have a cross-reaction.
在33例麻风病患者中，67%的患者血清中存在IgG或IgM抗心磷脂抗体；在30例结核病患者中，53%的患者血清中存在该抗体；在16例心内膜炎患者中，50%的患者血清中存在该抗体。尽管这些抗体出现的频率较高，但没有患者有血栓形成或流产史。对结核病患者和麻风病患者进行了抗变性DNA抗体检测。仅在后一组患者中，我们观察到抗心磷脂抗体与抗变性DNA抗体之间存在统计学上的显著关联。然而，血清与不同浓度的变性DNA预孵育并不能抑制抗心磷脂结合活性。这些数据表明：a）传染病中的抗心磷脂抗体不一定参与血栓形成或产科并发症的发病机制；b）在所研究的人群中，抗变性DNA抗体和抗心磷脂抗体没有交叉反应。
