Zhou Yong, Yi Xiaobin, Xing Wenxin, Hu Song, Maslov Konstantin I, Wang Lihong V
Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, Campus Box 1097, St. Louis, Missouri 63130, United States.
Washington University School of Medicine, Department of Anesthesiology/Pain Management, 660 South Euclid Avenue, Campus Box 8054, St. Louis, Missouri 63110, United States.
J Biomed Opt. 2014 Aug;19(8):086017. doi: 10.1117/1.JBO.19.8.086017.
Complex regional pain syndrome (CRPS) is a chronic pain syndrome that causes intractable pain, disability, and poor quality of life for patients. The etiology and pathophysiology of CRPS are still poorly understood. Due to a lack of proper diagnostic tools, the prognosis of CRPS is primarily based on clinical observation. The objective of this work is to evaluate a new imaging modality, photoacoustic microscopy (PAM), for assisting diagnoses and monitoring the progress and treatment outcome of CRPS. Blood vasculature and oxygen saturation (sO₂) were imaged by PAM from eight adult patients with CRPS-1. Patients' hands and cuticles were imaged both before and after stellate ganglion block (SGB) for comparison. For all patients, both vascular structure and sO₂ could be assessed by PAM. In addition, more vessels and stronger signals were observed after SGB. The results show that PAM can help diagnose and monitor CRPS.
复杂性区域疼痛综合征（CRPS）是一种慢性疼痛综合征，会给患者带来难以忍受的疼痛、功能障碍和生活质量下降。CRPS的病因和病理生理学仍未完全明确。由于缺乏合适的诊断工具，CRPS的预后主要基于临床观察。这项工作的目的是评估一种新的成像方式——光声显微镜（PAM），用于辅助诊断以及监测CRPS的病情进展和治疗效果。通过PAM对8名成人CRPS-1患者的血管系统和血氧饱和度（sO₂）进行成像。在星状神经节阻滞（SGB）前后对患者的手部和角质层进行成像以作比较。对于所有患者，PAM均可评估血管结构和sO₂。此外，在SGB后观察到更多的血管和更强的信号。结果表明，PAM有助于诊断和监测CRPS。
