Chen Hui, Jiang Wen
Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University Hangzhou, China.
Front Microbiol. 2014 Oct 13;5:508. doi: 10.3389/fmicb.2014.00508. eCollection 2014.
The oral microbiome is one of most diversity habitat in the human body and they are closely related with oral health and disease. As the technique developing, high-throughput sequencing has become a popular approach applied for oral microbial analysis. Oral bacterial profiles have been studied to explore the relationship between microbial diversity and oral diseases such as caries and periodontal disease. This review describes the application of high-throughput sequencing for characterization of oral microbiota and analyzing the changes of the microbiome in the states of health or disease. Deep understanding the knowledge of microbiota will pave the way for more effective prevent dentistry and contribute to the development of personalized dental medicine.
口腔微生物群是人体中最多样化的栖息地之一，它们与口腔健康和疾病密切相关。随着技术的发展，高通量测序已成为一种用于口腔微生物分析的常用方法。人们已经对口腔细菌谱进行了研究，以探索微生物多样性与龋齿和牙周病等口腔疾病之间的关系。这篇综述描述了高通量测序在口腔微生物群特征表征以及分析健康或疾病状态下微生物组变化方面的应用。深入了解微生物群的知识将为更有效的预防牙科铺平道路，并有助于个性化牙科医学的发展。
