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产KPC的肺炎克雷伯菌，最终将目标指向土耳其。

KPC-producing Klebsiella pneumoniae, finally targeting Turkey.

作者信息

Labarca J, Poirel L, Ozdamar M, Turkoglü S, Hakko E, Nordmann P

机构信息

INSERM U914 "Emerging Resistance to Antibiotics" K.-Bicêtre, France ; Departamento de Medicina Interna, Hospital Clínico Pontificia Universidad Católica de Chile Santiago, Chile.

INSERM U914 "Emerging Resistance to Antibiotics" K.-Bicêtre, France ; Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg Switzerland.

出版信息

New Microbes New Infect. 2014 Mar;2(2):50-1. doi: 10.1002/nmi2.42. Epub 2014 Mar 31.

DOI:10.1002/nmi2.42
PMID:25356342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4184591/
Abstract

We report here the first identification of the worldwide spread of Klebsiella pneumoniae carbapenemase-2-producing and carbapenem-resistant K. pneumoniae clone ST258 in Turkey, a country where the distantly-related carbapenemase OXA-48 is known to be endemic. Worryingly, this isolate was also resistant to colistin, now considered to be the last-resort antibiotic for carbapenem-resistant isolates.

摘要

我们在此报告，在土耳其首次发现产肺炎克雷伯菌碳青霉烯酶-2且对碳青霉烯类耐药的肺炎克雷伯菌克隆ST258在全球范围内传播。在这个国家，与之亲缘关系较远的碳青霉烯酶OXA-48已知为地方流行菌株。令人担忧的是，该分离株对黏菌素也耐药，而黏菌素目前被认为是耐碳青霉烯类分离株的最后一道抗生素防线。

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2
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Trends Mol Med. 2012 May;18(5):263-72. doi: 10.1016/j.molmed.2012.03.003. Epub 2012 Apr 3.
3
NDM-1-producing Klebsiella pneumoniae now in Turkey.产NDM-1的肺炎克雷伯菌现现身土耳其。
Antimicrob Agents Chemother. 2012 May;56(5):2784-5. doi: 10.1128/AAC.00150-12. Epub 2012 Mar 5.
4
Multiplex PCR for detection of acquired carbapenemase genes.多重 PCR 检测获得性碳青霉烯酶基因。
Diagn Microbiol Infect Dis. 2011 May;70(1):119-23. doi: 10.1016/j.diagmicrobio.2010.12.002. Epub 2011 Mar 12.
5
Identification of plasmids by PCR-based replicon typing.基于PCR的复制子分型鉴定质粒
J Microbiol Methods. 2005 Dec;63(3):219-28. doi: 10.1016/j.mimet.2005.03.018. Epub 2005 Jun 2.