具有空间模式化生物化学信号以控制细胞行为的纳米纤维水凝胶。
Nanofibrous hydrogels with spatially patterned biochemical signals to control cell behavior.
作者信息
Wade Ryan J, Bassin Ethan J, Gramlich William M, Burdick Jason A
机构信息
Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
出版信息
Adv Mater. 2015 Feb 25;27(8):1356-62. doi: 10.1002/adma.201404993. Epub 2015 Jan 12.
Abstract
The ability to spatially pattern biochemical signals into nanofibrous materials using thiol-ene reactions of thiolated molecules to presented norbornene groups is demonstrated. This approach is used to pattern three molecules independently within one scaffold, to pattern molecules through the depth of a scaffold, and to spatially control cell adhesion and morphology.
摘要
展示了利用硫醇化分子与呈现的降冰片烯基团的硫醇-烯反应将生化信号空间图案化到纳米纤维材料中的能力。这种方法用于在一个支架内独立地对三种分子进行图案化，在支架深度上对分子进行图案化，并在空间上控制细胞粘附和形态。
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J Mater Chem B. 2014 May 28;2(20):3029-3040. doi: 10.1039/c3tb21779e. Epub 2014 Apr 11.
2
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3
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Nat Commun. 2014 Jun 2;5:3935. doi: 10.1038/ncomms4935.
4
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J Mech Behav Biomed Mater. 2014 Oct;38:198-208. doi: 10.1016/j.jmbbm.2013.11.008. Epub 2013 Dec 4.
5
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7
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