Kim Dabin, Kim Gyoungmi, Nam Sang-Jip, Yin Jun, Yoon Juyoung
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea.
1] Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea [2] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan. 430079, P. R. China.
Sci Rep. 2015 Feb 16;5:8488. doi: 10.1038/srep08488.
Reactive oxygen species (ROS) play crucial roles in diverse physiological processes; therefore, the efficient detection of ROS is very crucial. In this study, we report a boronate-based hydrogen peroxide (H2O2) probe having naphthalimide fluorophore. This probe also contained a morpholine moiety as a directing group for lysosome. The recognition property indicated that the probe exhibited high selectivity towards H2O2 not only in the solution but also in the living cells. Furthermore, it was used to monitor the level of endogenous and exogenous H2O2. These results support that the probe can function as an efficient indicator to detect H2O2.
活性氧（ROS）在多种生理过程中发挥着关键作用；因此，高效检测ROS非常重要。在本研究中，我们报道了一种基于硼酸酯的具有萘酰亚胺荧光团的过氧化氢（H2O2）探针。该探针还含有吗啉部分作为溶酶体的导向基团。识别特性表明，该探针不仅在溶液中而且在活细胞中对H2O2都表现出高选择性。此外，它还被用于监测内源性和外源性H2O2的水平。这些结果表明该探针可作为检测H2O2的有效指示剂。
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