Smith Bennett E, Roder Paden B, Zhou Xuezhe, Pauzauskie Peter J
Department of Chemistry, University of Washington, Seattle, Washington, USA.
Nanoscale. 2015 Apr 28;7(16):7115-26. doi: 10.1039/c4nr06164k.
Recently, the use of nanoscale materials has attracted considerable attention with the aim of designing personalized therapeutic approaches that can enhance both spatial and temporal control over drug release, permeability, and uptake. Potential benefits to patients include the reduction of overall drug dosages, enabling the parallel delivery of different pharmaceuticals, and the possibility of enabling additional functionalities such as hyperthermia or deep-tissue imaging (LIF, PET, etc.) that complement and extend the efficacy of traditional chemotherapy and surgery. This mini-review is focused on an emerging class of nanometer-scale materials that can be used both to heat malignant tissue to reduce angiogenesis and DNA-repair while simultaneously offering complementary imaging capabilities based on radioemission, optical fluorescence, magnetic resonance, and photoacoustic methods.
最近，纳米级材料的应用引起了广泛关注，其目的是设计个性化治疗方法，以增强对药物释放、渗透性和摄取的时空控制。对患者的潜在益处包括降低总体药物剂量、实现不同药物的并行递送，以及实现诸如热疗或深部组织成像（激光诱导荧光、正电子发射断层扫描等）等附加功能的可能性，这些功能可补充并扩展传统化疗和手术的疗效。本综述聚焦于一类新兴的纳米级材料，这类材料可用于加热恶性组织以减少血管生成和DNA修复，同时基于放射发射、光学荧光、磁共振和光声方法提供互补的成像能力。
