常用根管封闭剂的生物毒性：一项荟萃分析。
Biotoxicity of commonly used root canal sealers: A meta-analysis.
作者信息
Kaur Amandeep, Shah Naseem, Logani Ajay, Mishra Navin
机构信息
Department of Conservative Dentistry and Endodontics, All India Institute of Medical Sciences, New Delhi, India.
出版信息
J Conserv Dent. 2015 Mar-Apr;18(2):83-8. doi: 10.4103/0972-0707.153054.
Abstract
INTRODUCTION
The main objective of a root canal sealer is to provide a fluid tight seal. The purpose of this systematic meta-analysis was to determine the relative toxicity of commonly used root canal sealers like zinc oxide eugenol, calcium hydroxide, and resin-based sealers.
MATERIALS AND METHODS
An online search was conducted in peer-reviewed journals listed in PubMed, Cochrane, EBSCO, and IndMed databases between 2000 and 2012). Statistical analysis was carried out by using analysis of variance (ANOVA) followed by post-hoc comparison by Bonferroni method. The comparison between toxicity at 24 h and between 3 and 7 days was done by using paired t-test for each sealer.
RESULTS
At 24 h, the relative biotoxicity of the three sealers reported was insignificant (P- value 0.29), but the difference in toxicity was found significant (P < 0.001) after 3 days.
CONCLUSION
Calcium hydroxide sealer and zinc oxide eugenol were found to be significantly biotoxic as compared to resin-based sealers after 3 days.
摘要
引言
根管封闭剂的主要目标是提供液密性密封。本系统荟萃分析的目的是确定常用根管封闭剂（如氧化锌丁香酚、氢氧化钙和树脂基封闭剂）的相对毒性。
材料与方法
在2000年至2012年期间，对PubMed、Cochrane、EBSCO和IndMed数据库中列出的同行评审期刊进行了在线搜索。采用方差分析（ANOVA）进行统计分析，随后采用Bonferroni法进行事后比较。通过对每种封闭剂使用配对t检验，对24小时时的毒性与3至7天之间的毒性进行比较。
结果
在24小时时，报告的三种封闭剂的相对生物毒性不显著（P值为0.29），但在3天后发现毒性差异显著（P < 0.001）。
结论
3天后发现，与树脂基封闭剂相比，氢氧化钙封闭剂和氧化锌丁香酚具有显著的生物毒性。
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