Ma Xing, Hahn Kersten, Sanchez Samuel
†Max Planck Institute for Intelligent Systems Institution, Heisenbergstraße 3, 70569 Stuttgart, Germany.
‡Institució Catalana de Recerca i EstudisAvancats (ICREA), Pg. Lluís Companys 23, 08010, Barcelona, Spain.
J Am Chem Soc. 2015 Apr 22;137(15):4976-9. doi: 10.1021/jacs.5b02700. Epub 2015 Apr 10.
We report on the synergy between catalytic propulsion and mesoporous silica nanoparticles (MSNPs) for the design of Janus nanomotors as active cargo delivery systems with sizes <100 nm (40, 65, and 90 nm). The Janus asymmetry of the nanomotors is given by electron beam (e-beam) deposition of a very thin platinum (2 nm) layer on MSNPs. The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %). Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion. Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.
我们报道了催化推进与介孔二氧化硅纳米颗粒（MSNP）之间的协同作用，用于设计尺寸小于100nm（40、65和90nm）的Janus纳米马达作为活性载药系统。纳米马达的Janus不对称性是通过在MSNP上电子束（e束）沉积非常薄的铂（2nm）层来实现的。化学驱动的Janus纳米马达在低过氧化氢燃料浓度（即<3wt%）下呈现活性扩散。与它们的布朗运动相比，其表观扩散系数提高了100%。由于它们的介孔结构和小尺寸，它们可以大量负载货物分子，并作为活性纳米载体在芯片上进行定向载药。
