Skyberg K, Hansteen I L, Jelmert O, Rønneberg A
Medical Department, Alcatel-STK A/S, Oslo, Norway.
Br J Ind Med. 1989 Nov;46(11):791-8. doi: 10.1136/oem.46.11.791.
Cytogenetic and haematological parameters were studied in 31 oil exposed workers and 31 office workers matched for age and smoking, all men employed by a Norwegian cable manufacturing company. Information was obtained about tobacco and alcohol consumption, infections, allergies, chronic diseases, use of medicines, and exposure to radiography. A decrease in the absolute lymphocyte counts was observed in the most heavily exposed subgroup (p less than 0.05) but no other significant differences were found between exposed workers and referents. The influence of non-occupational variables on the cytogenetic parameters was studied by stepwise multiple linear regression analysis. The frequency of sister chromatid exchanges appeared to be influenced by smoking history (p less than 0.05) and season of sampling (p less than 0.01) and, if season was excluded, by age (p less than 0.05) and current smoking (p less than 0.05). The number of cells with chromosomal aberrations increased with age (p less than 0.05) and lymphocyte count (p less than 0.05), whereas the frequency of stable rearrangements was negatively correlated with current smoking (p less than 0.01).
对31名接触石油的工人和31名年龄及吸烟情况相匹配的办公室职员进行了细胞遗传学和血液学参数研究，所有男性均受雇于一家挪威电缆制造公司。获取了有关烟草和酒精消费、感染、过敏、慢性病、药物使用以及放射摄影暴露的信息。在暴露程度最高的亚组中观察到绝对淋巴细胞计数下降（p<0.05），但在暴露工人与对照之间未发现其他显著差异。通过逐步多元线性回归分析研究了非职业变量对细胞遗传学参数的影响。姐妹染色单体交换频率似乎受吸烟史（p<0.05）和采样季节（p<0.01）影响，若排除季节因素，则受年龄（p<0.05）和当前吸烟情况（p<0.05）影响。有染色体畸变的细胞数量随年龄（p<0.05）和淋巴细胞计数（p<0.05）增加，而稳定重排频率与当前吸烟呈负相关（p<0.01）。
