Marshall Wallace F
Department of Biochemistry & Biophysics, University of California San Francisco, San Francisco, California 94158.
Cold Spring Harb Perspect Biol. 2015 May 8;7(6):a019059. doi: 10.1101/cshperspect.a019059.
All of the same conceptual questions about size in organisms apply equally at the level of single cells. What determines the size, not only of the whole cell, but of all of its parts? What ensures that subcellular components are properly proportioned relative to the whole cell? How does alteration in organelle size affect biochemical function? Answering such fundamental questions requires us to understand how the size of individual organelles and other cellular structures is determined. Knowledge of organelle biogenesis and dynamics has advanced rapidly in recent years. Does this knowledge give us enough information to formulate reasonable models for organelle size control, or are we still missing something?
关于生物体大小的所有相同概念性问题,在单细胞层面同样适用。是什么决定了细胞的大小,不仅是整个细胞的大小,还包括其所有部分的大小?是什么确保亚细胞组分相对于整个细胞具有恰当的比例?细胞器大小的改变如何影响生化功能?要回答这些基本问题,我们需要了解单个细胞器和其他细胞结构的大小是如何确定的。近年来,细胞器生物发生和动态变化方面的知识有了迅速进展。这些知识是否足以让我们构建合理的细胞器大小控制模型,还是我们仍然有所欠缺?