Heng Jun Khee, Koh Li Jia, Toh Matthias Paul Han Sim, Aw Derrick Chen Wee
Department of Medicine, National University Hospital, Singapore 119074, Singapore.
Department of Preventive Medicine, National University Hospital, Singapore 119074, Singapore.
Asia Pac Allergy. 2015 Oct;5(4):197-202. doi: 10.5415/apallergy.2015.5.4.197. Epub 2015 Oct 28.
Chronic urticaria is a common skin condition that causes significant impact on patient's quality of life.
The purpose of the study was to assess adherence to therapy and quality of life of patients with chronic urticaria. We also aimed to study the relationship of medication adherence and quality of life of patients with chronic urticaria.
A cross sectional study was conducted with 103 patients from the dermatology clinic of National University Hospital, Singapore. Patients with chronic urticaria were asked to fill out a questionnaire for assessment of adherence to therapy and quality of life. We used the Morisky 8-Item Medication Adherence Scale to categorize adherence as high, medium, low. For assessment of quality of life, we used the validated chronic urticaria quality of life questionnaire (CU-Q2oL) by Bairadani et al.
The highest median scores for the items measuring quality of life were interference with sleep and pruritus. We also observed that the majority of patients (71.9%) had low adherence to medical therapy. No difference in adherence was noted in patients on once daily medication or more frequent dosing. There was no significant difference in the quality of life among patients with low and medium adherence to therapy.
Quality of life of patients with chronic urticaria does not depend on the patients' adherence to medications. Dosing frequency does not affect adherence in our study population. It is also important to recognize the symptoms and issues most affecting quality of life of patients with chronic urticaria, so as to improve overall management.
慢性荨麻疹是一种常见的皮肤疾病，对患者的生活质量有显著影响。
本研究旨在评估慢性荨麻疹患者的治疗依从性和生活质量。我们还旨在研究慢性荨麻疹患者药物依从性与生活质量之间的关系。
对新加坡国立大学医院皮肤科门诊的103例患者进行了横断面研究。要求慢性荨麻疹患者填写一份问卷，以评估治疗依从性和生活质量。我们使用Morisky 8项药物依从性量表将依从性分为高、中、低三类。为了评估生活质量，我们使用了Bairadani等人验证的慢性荨麻疹生活质量问卷（CU-Q2oL）。
生活质量测量项目中得分中位数最高的是睡眠干扰和瘙痒。我们还观察到，大多数患者（71.9%）对药物治疗的依从性较低。每日一次用药或更频繁给药的患者在依从性方面没有差异。治疗依从性低和中等的患者在生活质量方面没有显著差异。
慢性荨麻疹患者的生活质量不取决于患者对药物的依从性。在我们的研究人群中，给药频率不影响依从性。认识到最影响慢性荨麻疹患者生活质量的症状和问题也很重要，以便改善整体管理。
