Jameson Victoria J A, Cochemé Helena M, Logan Angela, Hanton Lyall R, Smith Robin A J, Murphy Michael P
Department of Chemistry, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
MRC Clinical Sciences Centre, Imperial College, London, W12 0NN, UK ; MRC Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK.
Tetrahedron. 2015 Nov 4;71(44):8444-8453. doi: 10.1016/j.tet.2015.09.014.
A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo.
已经制备了一系列线粒体靶向抗氧化剂，其包含通过烷基连接基连接到维生素E的抗氧化色满部分的亲脂性三苯基鏻阳离子。一系列具有不同烷基连接基的线粒体靶向维生素E衍生物的合成得到了具有不同疏水性的化合物。这项工作将能够在体内确定抗氧化防御对疏水性的依赖性。
