Heath Christopher J, Phillips Benjamin U, Bussey Timothy J, Saksida Lisa M
Department of Psychology and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.
Curr Protoc Neurosci. 2016 Jan 4;74:8.34.1-8.34.20. doi: 10.1002/0471142301.ns0834s74.
This unit is designed to facilitate implementation of the fixed and progressive ratio paradigms and the effort-related choice task in the rodent touchscreen apparatus to permit direct measurement of motivation and reward-related decision making in this equipment. These protocols have been optimized for use in the mouse and reliably yield stable performance levels that can be enhanced or suppressed by systemic pharmacological manipulation. Instructions are also provided for the adjustment of task parameters to permit use in mouse models of neurodegenerative disease. These tasks expand the utility of the rodent touchscreen apparatus beyond the currently available battery of cognitive assessment paradigms.
本装置旨在便于在啮齿动物触屏设备中实施固定比率和累进比率范式以及与努力相关的选择任务，以便在该设备中直接测量动机和与奖励相关的决策。这些方案已针对小鼠进行了优化，并且可靠地产生稳定的性能水平，可通过全身药理学操作来增强或抑制。还提供了调整任务参数的说明，以便在神经退行性疾病的小鼠模型中使用。这些任务扩展了啮齿动物触屏设备的用途，超出了目前可用的一系列认知评估范式。
