Allergy Centre, Tampere University Hospital, Tampere, Finland.
Centre for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
Allergy. 2016 May;71(5):677-83. doi: 10.1111/all.12837. Epub 2016 Feb 8.
Several authors have reported on allergic reactions that resulted in presentation to the emergency department. However, studies of the secular trend of hospitalizations for paediatric allergic reactions, including anaphylaxis, are scarce. The aim of this study was to describe the secular trends of hospitalizations for allergic reactions, including anaphylaxis, among children aged 0-19 years in Finland and Sweden, and to establish the trend of prescribed epinephrine auto-injectors (EAI) among paediatric populations.
Using national databases, we identified hospitalizations between 1999 and 2011 with the primary diagnosis of allergic reaction per International Classification of Diseases, 10th Revision.
Hospitalizations for allergic reactions totalled 1987 in Finland and 5433 in Sweden. Incidence rates increased in both countries. In Finland, the incidence of admission was 7.8 per 100 000 person-years at the start of the study period and 15.8 at the end of the study period. The corresponding numbers among Swedish children were 13.7 and 31.8 per 100 000 person-years. In Finland, 60% of children hospitalized were aged under 10 years. In Sweden, this proportion was somewhat lower, at 48%. Most hospitalizations occurred between May and September. The prevalence of EAI prescriptions in Finland increased by fourfold during the study period. In Sweden, such an increase was not identified.
The incidence of allergic reactions leading to hospitalizations between 1999 and 2011 increased in Finland and Sweden among children aged 0 to 19 years. In Finland, the incidence was lower throughout the study period compared to Sweden. Younger children constituted the majority of hospitalized children.
有几位作者报道了导致急诊就诊的过敏反应。然而，关于包括过敏反应（过敏反应）在内的儿科过敏反应住院的时间趋势研究却很少。本研究的目的是描述芬兰和瑞典 0-19 岁儿童过敏反应（包括过敏反应）住院的时间趋势，并确定儿科人群中肾上腺素自动注射器（EAI）的使用趋势。
使用国家数据库，我们根据国际疾病分类，第 10 版确定了 1999 年至 2011 年期间以过敏反应为主要诊断的住院病例。
芬兰共发生过敏反应住院 1987 例，瑞典共发生 5433 例。两国的发病率均有所增加。在芬兰，研究开始时的入院率为每 100000 人年 7.8，研究结束时为 15.8。瑞典儿童的相应数字为每 100000 人年 13.7 和 31.8。在芬兰，60%的住院儿童年龄在 10 岁以下。在瑞典，这一比例略低，为 48%。大多数住院发生在 5 月至 9 月之间。芬兰 EAI 处方的流行率在研究期间增加了四倍。在瑞典，未发现这种增加。
1999 年至 2011 年间，芬兰和瑞典 0-19 岁儿童因过敏反应导致住院的发病率有所增加。在整个研究期间，芬兰的发病率均低于瑞典。年龄较小的儿童构成了住院儿童的大多数。
