Ding Chihong, Wu Xiaodan, Auckloo Bibi Nazia, Chen Chen-Tung Arthur, Ye Ying, Wang Kuiwu, Wu Bin
Ocean College, Zhejiang University, Hangzhou 310058, China.
Institute of Marine Geology and Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Molecules. 2016 Jan 16;21(1):105. doi: 10.3390/molecules21010105.
A novel hybrid polyketide-terpenoid, aspergstressin (1), possessing a unique fused polycyclic structure, was induced from culture broth of strain Aspergillus sp. WU 243 by cobalt ion stimulation. The strain was isolated from the digestive gland of Xenograpsus testudinatus, a unique type of crab which dwells in the Kueishantao hydrothermal vents off Taiwan. The chemical structure and relative configuration of the stress metabolite were established by spectroscopic means. Aspergillus sp. WU 243 produced aspergstressin (1) only under cobalt stressed culture conditions. The results show that stress-driven discovery of new natural products from hydrothermal vent fungi is an effective strategy to unveil the untapped reservoir of small molecules from species found in the hydrothermal vent environment.
一种新型的杂合聚酮化合物 - 萜类化合物，曲霉应激素（1），具有独特的稠合多环结构，通过钴离子刺激从曲霉属菌株WU 243的培养液中诱导产生。该菌株是从细纹蝉蟹的消化腺中分离出来的，细纹蝉蟹是一种生活在台湾龟山岛热液喷口的独特螃蟹。通过光谱手段确定了应激代谢产物的化学结构和相对构型。曲霉属菌株WU 243仅在钴胁迫培养条件下产生曲霉应激素（1）。结果表明，通过应激驱动从热液喷口真菌中发现新的天然产物是揭示热液喷口环境中物种未开发的小分子库的有效策略。
