Ocean College, Zhejiang University, Hangzhou 310058, China.
Mar Drugs. 2013 Aug 2;11(8):2713-21. doi: 10.3390/md11082713.
Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7β H-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11, 14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl2. Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC50 value of 14.8 µM and 22.3 µM.
两种新的倍半萜，1β,5α,6α,14-四乙酰氧基-9α-苯甲酰氧基-7β H-桉烷-2β,11-二醇（1）和 4α,5α-二乙酰氧基-9α-苯甲酰氧基-7βH-桉烷-1β,2β,11,14-四醇（2），作为胁迫代谢物在从藻类 Sargassum horneri 中分离出的 Pestalotiopsis sp. Z233 的培养菌丝中产生，以响应 CuCl2 引发的非生物胁迫。它们的结构通过光谱方法确定。新化合物 1 和 2 表现出酪氨酸酶抑制活性，IC50 值分别为 14.8 µM 和 22.3 µM。
