Huang Shenghai, Shen Meixiao, Zhu Dexi, Chen Qi, Shi Ce, Chen Zhongping, Lu Fan
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China; Co-first authors: they have contributed equally to the project.
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Biomed Opt Express. 2016 Jan 25;7(2):663-76. doi: 10.1364/BOE.7.000663. eCollection 2016 Feb 1.
Retinal hemodynamics is important for early diagnosis and precise monitoring in retinal vascular diseases. We propose a novel method for measuring absolute retinal blood flow in vivo using the combined techniques of optical coherence tomography (OCT) angiography and Doppler OCT. Doppler values can be corrected by Doppler angles extracted from OCT angiography images. A three-dimensional (3D) segmentation algorithm based on dynamic programming was developed to extract the 3D boundaries of optic disc vessels, and Doppler angles were calculated from 3D vessel geometry. The accuracy of blood flow from the Doppler OCT was validated using a flow phantom. The feasibility of the method was tested on a subject in vivo. The pulsatile retinal blood flow and the parameters for retinal hemodynamics were successfully obtained.
视网膜血流动力学对于视网膜血管疾病的早期诊断和精确监测至关重要。我们提出了一种使用光学相干断层扫描（OCT）血管造影和多普勒OCT的联合技术在体内测量绝对视网膜血流量的新方法。多普勒值可以通过从OCT血管造影图像中提取的多普勒角度进行校正。开发了一种基于动态规划的三维（3D）分割算法来提取视盘血管的3D边界，并根据3D血管几何形状计算多普勒角度。使用流动模型验证了多普勒OCT血流测量的准确性。在一名受试者体内测试了该方法的可行性。成功获得了搏动性视网膜血流量和视网膜血流动力学参数。
