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伯氏疏螺旋体对内皮细胞单层的穿透

Penetration of endothelial cell monolayers by Borrelia burgdorferi.

作者信息

Comstock L E, Thomas D D

机构信息

Department of Microbiology and Immunology, Bowman Gray School of Medicine, Wake Forest University Medical Center, Winston-Salem, North Carolina 27103.

出版信息

Infect Immun. 1989 May;57(5):1626-8. doi: 10.1128/iai.57.5.1626-1628.1989.

DOI:10.1128/iai.57.5.1626-1628.1989
PMID:2707862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC313325/
Abstract

The ability of Borrelia burgdorferi, the agent of Lyme disease, to penetrate cultured human umbilical vein endothelial cell monolayers was investigated. After 4 h of coincubation, approximately 7.7% of added bacteria passed through the host cell monolayers. Electron microscopy revealed that the borreliae entered the endothelial cells and suggested that the organisms penetrated the host monolayers primarily by passing through them.

摘要

对莱姆病病原体伯氏疏螺旋体穿透培养的人脐静脉内皮细胞单层的能力进行了研究。共孵育4小时后，约7.7%的添加细菌穿过宿主细胞单层。电子显微镜显示疏螺旋体进入了内皮细胞，并表明该生物体主要通过穿过宿主单层来穿透它们。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555e/313325/ed51b33b213d/iai00065-0287-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555e/313325/ed51b33b213d/iai00065-0287-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555e/313325/ed51b33b213d/iai00065-0287-a.jpg

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Lyme disease-a tick-borne spirochetosis?莱姆病——一种蜱传播的螺旋体病？
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A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.共同作用：莱姆关节炎中固有免疫系统与适应性免疫系统之间的相互作用
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Infect Immun. 1984 May;44(2):205-10. doi: 10.1128/iai.44.2.205-210.1984.
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Isolation and cultivation of Lyme disease spirochetes.莱姆病螺旋体的分离与培养。
Yale J Biol Med. 1984 Jul-Aug;57(4):521-5.
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Adherence of Candida to cultured vascular endothelial cells: mechanisms of attachment and endothelial cell penetration.
J Infect Dis. 1985 Dec;152(6):1264-74. doi: 10.1093/infdis/152.6.1264.
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Penetration of Salmonella through a polarized Madin-Darby canine kidney epithelial cell monolayer.鼠伤寒沙门氏菌穿过极化的麦迪逊-达比犬肾上皮细胞单层的穿透情况。
J Cell Biol. 1988 Jul;107(1):221-30. doi: 10.1083/jcb.107.1.221.
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Treponema pallidum invades intercellular junctions of endothelial cell monolayers.梅毒螺旋体侵入内皮细胞单层的细胞间连接。
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Interaction of Lyme disease spirochetes with cultured eucaryotic cells.莱姆病螺旋体与培养的真核细胞的相互作用。
Infect Immun. 1989 Apr;57(4):1324-6. doi: 10.1128/iai.57.4.1324-1326.1989.
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Isolation of the outer envelope from Borrelia burgdorferi.从伯氏疏螺旋体中分离外膜。
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Heterogeneity of major proteins in Lyme disease borreliae: a molecular analysis of North American and European isolates.莱姆病疏螺旋体主要蛋白质的异质性：北美和欧洲分离株的分子分析
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