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莱姆病螺旋体与培养的真核细胞的相互作用。

Interaction of Lyme disease spirochetes with cultured eucaryotic cells.

作者信息

Thomas D D, Comstock L E

机构信息

Department of Microbiology and Immunology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.

出版信息

Infect Immun. 1989 Apr;57(4):1324-6. doi: 10.1128/iai.57.4.1324-1326.1989.

DOI:10.1128/iai.57.4.1324-1326.1989
PMID:2925254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC313270/
Abstract

The association of the Lyme disease spirochete, Borrelia burgdorferi, with cultured human endothelial cells was investigated. Attachment was time and temperature dependent, with optimal adherence occurring after 4 h of incubation at 37 degrees C. Pretreatment of borreliae with heat, immune human serum, or monoclonal antibodies directed against outer surface protein B (OspB) reduced the attachment of organisms to host cell monolayers. These results suggest that the adherence of B. burgdorferi may be mediated, at least in part, by borrelial surface proteins.

摘要

对莱姆病螺旋体——伯氏疏螺旋体与培养的人内皮细胞之间的关联进行了研究。黏附具有时间和温度依赖性，在37摄氏度孵育4小时后出现最佳黏附。用热、免疫人血清或针对外表面蛋白B（OspB）的单克隆抗体对疏螺旋体进行预处理，可减少微生物与宿主细胞单层的黏附。这些结果表明，伯氏疏螺旋体的黏附可能至少部分地由疏螺旋体表面蛋白介导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f048/313270/c6bed0ae3af5/iai00064-0327-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f048/313270/c6bed0ae3af5/iai00064-0327-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f048/313270/c6bed0ae3af5/iai00064-0327-a.jpg

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本文引用的文献

1
Lyme disease-a tick-borne spirochetosis?莱姆病——一种蜱传播的螺旋体病？
Science. 1982 Jun 18;216(4552):1317-9. doi: 10.1126/science.7043737.
2
Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.细菌黏附：介导细菌附着于黏膜表面的黏附素-受体相互作用。
J Infect Dis. 1981 Mar;143(3):325-45. doi: 10.1093/infdis/143.3.325.
3
Molecular characterization of receptor binding proteins and immunogens of virulent Treponema pallidum.梅毒螺旋体强毒株受体结合蛋白和免疫原的分子特征分析
在不同人类细胞系中实现持久性的独特逃避机制。
Front Microbiol. 2021 Oct 12;12:711291. doi: 10.3389/fmicb.2021.711291. eCollection 2021.
4
Keeps Moving and Carries on: A Review of Borrelial Dissemination and Invasion.持续传播与侵袭：莱姆病螺旋体传播与侵袭的综述
Front Immunol. 2017 Feb 21;8:114. doi: 10.3389/fimmu.2017.00114. eCollection 2017.
5
Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete.宿主细胞硫酸乙酰肝素糖胺聚糖是莱姆病螺旋体中与OspF相关蛋白的配体。
Cell Microbiol. 2015 Oct;17(10):1464-76. doi: 10.1111/cmi.12448. Epub 2015 May 13.
6
Enhanced Adhesion and OspC Protein Synthesis of the Lyme Disease Spirochete Borrelia Burgdorferi Cultivated in a Host-Derived Tissue Co-Culture System.在宿主来源的组织共培养系统中培养的莱姆病螺旋体伯氏疏螺旋体增强的黏附和 ospC 蛋白合成。
Balkan Med J. 2013 Jun;30(2):215-24. doi: 10.5152/balkanmedj.2013.7059. Epub 2013 Jun 1.
7
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10
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4
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5
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6
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7
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10
Update: Lyme disease and cases occurring during pregnancy--United States.
MMWR Morb Mortal Wkly Rep. 1985 Jun 28;34(25):376-8, 383-4.