Groeseneken D, Veulemans H, Masschelein R, Van Vlem E
Laboratory of Occupational Hygiene and Toxicology, K.U. Leuven, Belgium.
Int Arch Occup Environ Health. 1989;61(4):243-7. doi: 10.1007/BF00381421.
The uptake of EGME and the urinary excretion of its major metabolite (MAA) was studied in seven male volunteers during experimental exposure to EGME at rest. The exposure concentration was set at 16 mg/m3, the present Threshold Limit Value. A high retention (0.76) remained unchanged during the 4-h exposure period. In combination with a constant pulmonary ventilation and a fixed exposure concentration this resulted in an uptake rate that showed no significant variation in time. The total amount of EGME inhaled corresponded to a dose of only 0.25 mg/kg. During and up to 120 h after the start of the exposure, MAA was detected in the urine. The elimination half-life was on average 77.1 h. The total amount of MAA excreted was calculated by extrapolation and averaged 85.5% of the inhaled EGME. The pharmacokinetic data are compared with those obtained from other human exposure studies to ethylene glycol ethers (EGEE and EGBE).
在七名男性志愿者静息状态下实验性接触乙二醇甲醚（EGME）期间，研究了EGME的摄取及其主要代谢产物（甲氧基乙酸，MAA）的尿排泄情况。暴露浓度设定为16mg/m³，即当前的阈限值。在4小时的暴露期间，高潴留率（0.76）保持不变。结合恒定的肺通气量和固定的暴露浓度，这导致摄取率在时间上无显著变化。吸入的EGME总量仅相当于0.25mg/kg的剂量。在暴露开始后直至120小时期间及之后，尿液中均检测到MAA。消除半衰期平均为77.1小时。通过外推法计算得出排泄的MAA总量，平均为吸入的EGME的85.5%。将这些药代动力学数据与从其他关于乙二醇醚（EGEE和EGBE）的人体暴露研究中获得的数据进行了比较。
