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一项系统评价：孕期使用草药和顺势疗法药物是否安全？

A systematic review: Are herbal and homeopathic remedies used during pregnancy safe?

作者信息

Boltman-Binkowski Haaritha

机构信息

Advanced Midwifery and Neonatal Nursing, University of the Western Cape.

出版信息

Curationis. 2016 Apr 13;39(1):1514. doi: 10.4102/curationis.v39i1.1514.

DOI:10.4102/curationis.v39i1.1514
PMID:27246791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6091622/
Abstract

BACKGROUND

Herbal and homeopathic remedies have been used to assist with child bearing and pregnancy for centuries. Allopathic ('Western') medicine is traditionally avoided during pregnancy because of limited drug trials and the suspected teratogenic effects of these medications. This has led to an increase in the use of herbal and homeopathic remedies, asthey are viewed to have no teratogenic effect on the developing foetus. Health providers are faced with questions from their clients regarding the safety of these remedies, but much of the evidence about these herbal and homeopathic remedies is anecdotal and few remedies havebeen tested scientifically.

OBJECTIVES

By conducting a systematic review, the primary objective was to evaluate maternal and neonatal outcomes of ingested herbal and homeopathic remedies during pregnancy.

METHOD

A systematic review was conducted to synthesise all the evidence with the purpose of evaluating the safety of herbal and homeopathic remedies based on adverse maternal and neonatal outcomes. Only randomised and quasi-randomised controlled trials that met allinclusion criteria were included in the review.

RESULTS

The ingestion of ginger for nausea and vomiting during pregnancy was shown to have no harmful maternal or neonatal effects. Ingestion of castor oil for induction of labour showed a tendency towards an increase in the incidence of caesarean section and meconiumstained liquor, warranting further research into its safety issues.

CONCLUSION

Larger randomised controlled trials need to be conducted, especially in South Africa, to establish the safety and efficacy of commonly-used remedies.

摘要

背景

几个世纪以来，草药和顺势疗法药物一直被用于辅助生育和孕期保健。由于药物试验有限以及怀疑这些药物有致畸作用，孕期传统上避免使用对抗疗法（“西方”）药物。这导致草药和顺势疗法药物的使用增加，因为它们被认为对发育中的胎儿没有致畸作用。医疗服务提供者面临客户关于这些药物安全性的问题，但关于这些草药和顺势疗法药物的许多证据都是传闻，很少有药物经过科学测试。

目的

通过进行系统评价，主要目的是评估孕期摄入草药和顺势疗法药物对母婴结局的影响。

方法

进行了一项系统评价，综合所有证据，目的是根据不良母婴结局评估草药和顺势疗法药物的安全性。该评价仅纳入符合所有纳入标准的随机和半随机对照试验。

结果

孕期服用生姜治疗恶心和呕吐对母亲或新生儿没有有害影响。服用蓖麻油引产显示剖宫产和羊水胎粪污染的发生率有增加趋势，需要进一步研究其安全性问题。

结论

需要进行更大规模的随机对照试验，尤其是在南非，以确定常用药物的安全性和有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/8183cd714f6f/CUR-39-1514-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/ca9f8c0942dd/CUR-39-1514-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/8b2ae65603d7/CUR-39-1514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/bc7f9c40adcc/CUR-39-1514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/a6e0f00f323a/CUR-39-1514-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/1f3a36299929/CUR-39-1514-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/cefaae0ad015/CUR-39-1514-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/8183cd714f6f/CUR-39-1514-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/ca9f8c0942dd/CUR-39-1514-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/8b2ae65603d7/CUR-39-1514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/bc7f9c40adcc/CUR-39-1514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/a6e0f00f323a/CUR-39-1514-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/1f3a36299929/CUR-39-1514-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/cefaae0ad015/CUR-39-1514-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2338/6091622/8183cd714f6f/CUR-39-1514-g007.jpg

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本文引用的文献

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