Arnold Jason W, Roach Jeffrey, Azcarate-Peril M Andrea
Department of Cell Biology and Physiology, and Microbiome Core Facility, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Research Computing, University of North Carolina, Chapel Hill, NC, USA.
Trends Microbiol. 2016 Nov;24(11):887-901. doi: 10.1016/j.tim.2016.06.008. Epub 2016 Jul 15.
Understanding the importance of the gut microbiome on modulation of host health has become a subject of great interest for researchers across disciplines. As an intrinsically multidisciplinary field, microbiome research has been able to reap the benefits of technological advancements in systems and synthetic biology, biomaterials engineering, and traditional microbiology. Gut microbiome research has been revolutionized by high-throughput sequencing technology, permitting compositional and functional analyses that were previously an unrealistic undertaking. Emerging technologies, including engineered organoids derived from human stem cells, high-throughput culturing, and microfluidics assays allowing for the introduction of novel approaches, will improve the efficiency and quality of microbiome research. Here, we discuss emerging technologies and their potential impact on gut microbiome studies.
了解肠道微生物群对宿主健康调节的重要性已成为各学科研究人员极为关注的课题。作为一个本质上跨学科的领域，微生物群研究已经能够从系统生物学和合成生物学、生物材料工程以及传统微生物学等技术进步中获益。高通量测序技术彻底改变了肠道微生物群的研究，使得以前无法实现的组成和功能分析成为可能。包括源自人类干细胞的工程化类器官、高通量培养以及允许引入新方法的微流控分析在内的新兴技术，将提高微生物群研究的效率和质量。在此，我们讨论新兴技术及其对肠道微生物群研究的潜在影响。
