Wang Lei, Wang Jianfeng, Liu Xudong, Liu Qian, Zhang Guozhuan, Liang Lishuang
Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.
Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China
Biosci Rep. 2016 Oct 14;36(5). doi: 10.1042/BSR20160345. Print 2016 Oct.
Quantification of the association between the intake of selenium and risk of pancreatic cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of selenium intake with the risk of pancreatic cancer. Pertinent studies were identified by a search of PubMed and Web of Knowledge to July 2016. The random-effect model was used. Sensitivity analysis and publication bias were conducted. Data from six studies including 1424 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest selenium intake amount compared with lowest amount was significantly associated with the risk of pancreatic cancer [summary relative risk (RR)=0.659, 95% confidence interval (CI)=0.489-0.889, I=47.6%]. The associations were significant both in case-control studies [RR=0.618, 95%CI=0.399-0.956, I=59.1%] and Americas [RR=0.570, 95%CI=0.357-0.909, I=65.6%]. No publication bias was found. Our analysis suggested that the higher intake of selenium might reduce the risk of pancreatic cancer.
硒摄入量与胰腺癌风险之间关联的量化研究结果仍存在争议。因此，我们进行了一项荟萃分析，以总结硒摄入量与胰腺癌风险的流行病学研究证据。通过检索截至2016年7月的PubMed和Web of Knowledge来确定相关研究。采用随机效应模型。进行了敏感性分析和发表偏倚分析。本荟萃分析使用了六项研究的数据，包括1424例胰腺癌病例。汇总结果表明，与最低硒摄入量相比，最高硒摄入量与胰腺癌风险显著相关[汇总相对风险（RR）=0.659，95%置信区间（CI）=0.489 - 0.889，I² = 47.6%]。在病例对照研究[RR = 0.618，95%CI = 0.399 - 0.956，I² = 59.1%]和美洲地区的研究[RR = 0.570，95%CI = 0.357 - 0.909，I² = 65.6%]中，这种关联均显著。未发现发表偏倚。我们的分析表明，较高的硒摄入量可能会降低胰腺癌风险。
