Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Liaoning Women and Children's Health Hospital, Shenyang, China.
Sci Rep. 2016 Sep 14;6:33333. doi: 10.1038/srep33333.
To identify trends in the prevalence of gastroschisis on the basis of a large population-based observation study with cases identified by the Liaoning Birth Defects Registry including 14 cities over the course of a 10-year period. Data were obtained from the aforementioned registry which was maintained by the Liaoning Women and Children's Health Hospital, a comprehensive care institution as well as being responsible for the women's and children's health care guidance in this province. Gastroschisis prevalence, percent change, annual percent change (APC), and contribution rates of each city were calculated. We observed 747 cases of gastroschisis among 3,248,954 live births, for a prevalence of 2.30 per 10,000 births. The gastroschisis prevalence significantly decreased by 12.63% per year in Liaoning Province. Although the decreasing trends were observed in all these 14 cities, significant results were only observed in Shenyang (APC = -16.31%), Tieling (APC = -20.23%), and Chaoyang (APC = -13.50%). Notably, Tieling, Shenyang, and Yingkou were the three major cities which contributed almost 37.17% of the decreasing trend of gastroschisis in Liaoning Province. In conclusion, our findings demonstrate that the prevalence of gastroschisis has been decreasing during the recent decade among 14 cities in Liaoning Province.
为了在一项基于人群的大型观察研究的基础上确定腹裂的流行趋势，我们通过辽宁省出生缺陷监测系统确定了病例，该系统包括辽宁省的 14 个城市，历时 10 年。数据来自辽宁省妇幼保健院维护的上述监测系统，该机构是一家综合性医疗机构，负责该省的妇女和儿童保健指导。计算了腹裂的流行率、百分比变化、年百分比变化（APC）和每个城市的贡献率。我们观察到 3248954 例活产儿中有 747 例腹裂，患病率为每 10000 例活产儿 2.30 例。辽宁省的腹裂患病率每年显著下降 12.63%。尽管所有 14 个城市都观察到了下降趋势，但只有沈阳（APC=-16.31%）、铁岭（APC=-20.23%）和朝阳（APC=-13.50%）的结果具有统计学意义。值得注意的是，铁岭、沈阳和营口是辽宁省腹裂患病率下降趋势的三个主要城市，占下降趋势的近 37.17%。总之，我们的研究结果表明，在过去十年中，辽宁省的 14 个城市中，腹裂的患病率一直在下降。
