在一例囊性纤维化病例中，膳食硝酸盐可急性且显著增加呼出气一氧化氮水平。
Dietary Nitrate Acutely and Markedly Increased Exhaled Nitric Oxide in a Cystic Fibrosis Case.
作者信息
Kerley Conor P, Kilbride Emma, Greally Peter, Elnazir Basil
机构信息
Paediatric Respiratory Department, National Children's Hospital, Dublin 24, Ireland
School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin 4, Ireland.
出版信息
Clin Med Res. 2016 Dec;14(3-4):151-155. doi: 10.3121/cmr.2016.1320. Epub 2016 Sep 14.
Abstract
Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is reduced to nitrite and NO. We present the case of a 12-year-old, athletic boy with CF who demonstrated acute but marked increases in exhaled NO following dietary nitrate consumption compared to placebo.
摘要
气道一氧化氮（NO）是一种普遍存在的信号分子，具有支气管保护、抗炎和抗感染作用。囊性纤维化（CF）是一种与呼出NO减少相关的慢性肺部疾病。增加CF患者呼出NO的策略产生了不一致的结果。一种潜在的增加全身NO的新方法是摄入膳食中的无机硝酸盐，其可还原为亚硝酸盐和NO。我们报告了一名12岁的患有CF的运动男孩的病例，与服用安慰剂相比，其在摄入膳食硝酸盐后呼出NO出现急性但显著的增加。
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