Xie Jiangfan, Yao Bin, Han Yutong, Huang Sha, Fu Xiaobing
Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to General Hospital of PLA, 51 Fu Cheng Road, Beijing, 100048 People's Republic of China.
Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to General Hospital of PLA, 51 Fu Cheng Road, Beijing, 100048 People's Republic of China ; School of Medicine, Nankai University, Tianjin, 300052 People's Republic of China.
Burns Trauma. 2016 Oct 26;4:38. doi: 10.1186/s41038-016-0064-6. eCollection 2016.
Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells also participate in the repair of the epidermis after injuries, inducing restoration of tissue integrity and function of damaged tissue. Unlike epidermis-derived stem cells, comprehensive knowledge about skin appendage-derived stem cells remains limited. In this review, we summarize the current knowledge of skin appendage-derived stem cells, including their fundamental characteristics, their preferentially expressed biomarkers, and their potential contribution involved in wound repair. Finally, we will also discuss current strategies, future applications, and limitations of these stem cells, attempting to provide some perspectives on optimizing the available therapy in cutaneous repair and regeneration.
存在于表皮和皮肤附属器中的干细胞对于皮肤的稳态和再生至关重要。这些干细胞还参与损伤后表皮的修复,促使受损组织的完整性和功能得以恢复。与表皮来源的干细胞不同,关于皮肤附属器来源的干细胞的全面认识仍然有限。在这篇综述中,我们总结了目前关于皮肤附属器来源的干细胞的知识,包括它们的基本特征、优先表达的生物标志物以及它们在伤口修复中的潜在作用。最后,我们还将讨论这些干细胞的当前策略、未来应用和局限性,试图为优化皮肤修复和再生的现有治疗方法提供一些观点。