中国腹泻犬中新型柯布病毒的分子特征分析
Molecular characterization of new described kobuvirus in dogs with diarrhea in China.
作者信息
Kong Ning, Zuo Yewen, Wang Zhongze, Yu Hai, Zhou En-Min, Shan Tongling, Tong Guangzhi
机构信息
Department of Swine Infectious Disease, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241 China ; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009 China ; Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100 China.
Department of Swine Infectious Disease, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241 China.
出版信息
Springerplus. 2016 Nov 30;5(1):2047. doi: 10.1186/s40064-016-3738-4. eCollection 2016.
Canine kobuvirus (CaKVs) was a newly described virus detected in dogs in the US and Italy. To learn more about CaKVs, 5 of 106 fecal samples from diarrhea dogs were positive with CaKVs in China, and the full genome of CaKVs strain CH-1 isolated from dog with diarrhea was sequenced. The genome consists of 8186 nucleotides, excluding the 3' poly (A) tail, and an open reading frame that maps between nucleotide positions 601 and 7943 which encodes a 2446 amino acid polyprotein. Based on the complete amino acid sequence of polyprotein, phylogenetic analysis showed that CH-1 was grouped along with other canine kobuvirus strains detected in the USA (US-PC0082, AN211D).
犬科杯状病毒（CaKVs）是一种新发现的病毒，在美国和意大利的犬类中被检测到。为了进一步了解CaKVs，在中国，106份腹泻犬粪便样本中有5份检测出CaKVs呈阳性，并对从腹泻犬中分离出的CaKVs毒株CH-1进行了全基因组测序。该基因组由8186个核苷酸组成，不包括3' 聚腺苷酸尾，其开放阅读框位于核苷酸位置601至7943之间，编码一个2446个氨基酸的多聚蛋白。基于多聚蛋白的完整氨基酸序列进行系统发育分析表明，CH-1与在美国检测到的其他犬科杯状病毒毒株（US-PC0082、AN211D）归为一类。
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