用MSP-1表面蛋白复合物对牛进行免疫接种可诱导产生针对结构变异的边缘无形体分离株的保护作用。
Immunization of cattle with the MSP-1 surface protein complex induces protection against a structurally variant Anaplasma marginale isolate.
作者信息
Palmer G H, Barbet A F, Cantor G H, McGuire T C
机构信息
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
出版信息
Infect Immun. 1989 Nov;57(11):3666-9. doi: 10.1128/iai.57.11.3666-3669.1989.
The Anaplasma marginale surface protein complex MSP-1 of the Florida isolate is composed of a 105-kilodalton (kDa) polypeptide, which bears a neutralization-sensitive epitope, and a 100-kDa polypeptide. Antigenically similar polypeptides in the Okanogan, Wash. (Washington-O), isolate MSP-1 are 86 and 100 kDa, respectively. Immunization of cattle with Florida isolate MSP-1 induced antibody titers to both MSP-1 polypeptides and protected cattle against homologous and heterologous challenge.
佛罗里达分离株的边缘无形体表面蛋白复合物MSP-1由一个带有中和敏感表位的105千道尔顿（kDa）多肽和一个100 kDa多肽组成。华盛顿州奥卡诺根（Washington-O）分离株MSP-1中抗原性相似的多肽分别为86 kDa和100 kDa。用佛罗里达分离株MSP-1免疫牛可诱导产生针对两种MSP-1多肽的抗体效价，并保护牛免受同源和异源攻击。
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