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用MSP-1表面蛋白复合物对牛进行免疫接种可诱导产生针对结构变异的边缘无形体分离株的保护作用。

Immunization of cattle with the MSP-1 surface protein complex induces protection against a structurally variant Anaplasma marginale isolate.

作者信息

Palmer G H, Barbet A F, Cantor G H, McGuire T C

机构信息

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.

出版信息

Infect Immun. 1989 Nov;57(11):3666-9. doi: 10.1128/iai.57.11.3666-3669.1989.

DOI:10.1128/iai.57.11.3666-3669.1989
PMID:2807542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC259883/
Abstract

The Anaplasma marginale surface protein complex MSP-1 of the Florida isolate is composed of a 105-kilodalton (kDa) polypeptide, which bears a neutralization-sensitive epitope, and a 100-kDa polypeptide. Antigenically similar polypeptides in the Okanogan, Wash. (Washington-O), isolate MSP-1 are 86 and 100 kDa, respectively. Immunization of cattle with Florida isolate MSP-1 induced antibody titers to both MSP-1 polypeptides and protected cattle against homologous and heterologous challenge.

摘要

佛罗里达分离株的边缘无形体表面蛋白复合物MSP-1由一个带有中和敏感表位的105千道尔顿（kDa）多肽和一个100 kDa多肽组成。华盛顿州奥卡诺根（Washington-O）分离株MSP-1中抗原性相似的多肽分别为86 kDa和100 kDa。用佛罗里达分离株MSP-1免疫牛可诱导产生针对两种MSP-1多肽的抗体效价，并保护牛免受同源和异源攻击。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e684/259883/2dfce1dacf99/iai00071-0419-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e684/259883/76e833c5cabc/iai00071-0419-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e684/259883/2dfce1dacf99/iai00071-0419-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e684/259883/76e833c5cabc/iai00071-0419-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e684/259883/2dfce1dacf99/iai00071-0419-b.jpg

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本文引用的文献

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Anaplasmosis. XI. Immunoserologic characteristics of the parasites present in the blood of calves infected with the Oregon strain of Anaplasma marginale.无形体病。十一。感染边缘无浆体俄勒冈株的犊牛血液中存在的寄生虫的免疫血清学特征。
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Anaplasmosis. X. Morphologic characteristics of the parasites present in the blood of calves infected with the Oregon strain of Anaplasma marginale.无形体病。十、感染边缘无浆体俄勒冈株的犊牛血液中存在的寄生虫的形态学特征。
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Comparison of three methods of immunization against bovine anaplasmosis: evaluation of protection afforded against field challenge exposure.
用Msp2高变区进行免疫接种预防无形体病的效果不如活疫苗。
Vaccines (Basel). 2023 Sep 29;11(10):1544. doi: 10.3390/vaccines11101544.
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Rickettsia and Anaplasma species in Dermacentor andersoni ticks from Washington.华盛顿硬蜱中的立克次体和无形体属物种。
Ticks Tick Borne Dis. 2020 Jul;11(4):101422. doi: 10.1016/j.ttbdis.2020.101422. Epub 2020 Apr 6.
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Anaplasma marginale and A. phagocytophilum in cattle in Tunisia.突尼斯牛体内的边缘无形体和嗜吞噬细胞无形体。
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Investigation of Anaplasma marginale Seroprevalence in a Traditionally Managed Large California Beef Herd.加利福尼亚州一个传统管理的大型肉牛群中边缘无形体血清阳性率的调查
Vet Med Int. 2016;2016:6186078. doi: 10.1155/2016/6186078. Epub 2016 Aug 28.
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Anaplasma marginale: Diversity, Virulence, and Vaccine Landscape through a Genomics Approach.边缘无形体：通过基因组学方法探究其多样性、毒力及疫苗前景
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Am J Vet Res. 1984 Nov;45(11):2223-6.
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Science. 1986 Mar 14;231(4743):1299-302. doi: 10.1126/science.3945825.