Li Jiu Wei, Gao Xiao Yan, Wu Yun, Fu Shi Hong, Tan Xiao Juan, Cao Yu Xi, Zhang Wei Hua, Yin Zun Dong, He Ying, Li Yi Xing, Liang Guo Dong, Xu Wen Bo, Fang Fang, Wang Huan Yu
Neurology Department, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
Department of Viral Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; State Key Laboratory for Infectious Disease Prevention and Control (SKLID), Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Biomed Environ Sci. 2016 Dec;29(12):902-908. doi: 10.3967/bes2016.121.
Fifteen pediatric cases of suspected Japanese encephalitis (JE) were reported in Beijing Children's Hospital during the late summer of 2013. The clinical manifestations in most cases included high fever, seizures, and abnormal magnetic resonance imaging findings. Twelve of 15 cases were laboratory-confirmed as JE cases by pathogen identification. Epidemiological investigations showed that five of the 12 laboratory-confirmed patients had an incomplete JE vaccination history. Follow-up investigations after discharge indicated that seven laboratory-confirmed JE patients without JE vaccinations had relatively poor prognoses, with an average Modified Rankin Scale (MRS) score of 2.6 when compared with the other five laboratory-confirmed, JE-vaccinated patients with an average MRS score of 0.5. The observation of pediatric JE cases among those with a history of JE vaccination warrants further attention.
2013年夏末，北京儿童医院报告了15例疑似日本脑炎（乙脑）的儿科病例。多数病例的临床表现包括高热、惊厥以及磁共振成像检查结果异常。15例中有12例经病原体鉴定被实验室确诊为乙脑病例。流行病学调查显示，12例实验室确诊患者中有5例乙脑疫苗接种史不完整。出院后的随访调查表明，7例未接种乙脑疫苗的实验室确诊乙脑患者预后相对较差，改良Rankin量表（MRS）平均评分为2.6，而其他5例接种过乙脑疫苗的实验室确诊患者MRS平均评分为0.5。对有乙脑疫苗接种史儿童乙脑病例的观察值得进一步关注。
