Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, Republic of Korea.
Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, Republic of Korea; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Neurosci Biobehav Rev. 2017 Apr;75:183-194. doi: 10.1016/j.neubiorev.2017.01.049. Epub 2017 Feb 4.
As a major component of the hippocampal trisynaptic circuit, the dentate gyrus (DG) relays inputs from the entorhinal cortex to the CA3 subregion. Although the anatomy of the DG is well characterized, its contribution to hippocampal mnemonic processing is still unclear. A currently popular theory proposes that the primary function of the DG is to orthogonalize incoming input patterns into non-overlapping patterns (pattern separation). We critically review the available data and conclude that the theoretical support and empirical evidence for this theory are not strong. We then review an alternative theory that posits a role for the DG in binding together different types of incoming sensory information. We conclude that 'binding' better captures the contribution of the DG to memory encoding than 'pattern separation'.
作为海马三突触回路的主要组成部分，齿状回（DG）将来自内嗅皮层的输入传递到 CA3 亚区。尽管 DG 的解剖结构已经得到很好的描述，但它对海马记忆处理的贡献仍不清楚。目前流行的一种理论认为，DG 的主要功能是将传入的输入模式正交化为不重叠的模式（模式分离）。我们批判性地回顾了现有数据，并得出结论，该理论的理论支持和经验证据并不充分。然后，我们回顾了另一种理论，该理论假设 DG 在将不同类型的传入感觉信息绑定在一起方面发挥作用。我们得出结论，“绑定”比“模式分离”更能捕捉 DG 对记忆编码的贡献。
