Einhorn S, Blomgren H, Strander H
Acta Med Scand. 1978;204(6):477-83.
The spontaneous cytotoxicity of peripheral lymphoid cells from five tumor patients was measured before and at various times after the first injection of human leukocyte interferon (IF). Four of the patients' lymphocytes exhibited cytotoxicity before the IF injection. After injection of IF there was an initial decrease in cytotoxicity, followed by an increase to 1.5-5 times above the preinjection level, the peak being reached at 12 hours. Thereafter the spontaneous cytotoxicity decreased but usually remained elevated for 24 hours after the injection. The lymphocytes of the fifth patient had very low spontaneous cytotoxicity before the injection of IF, and this did not markedly change afterwards. The proportion of E-rosette forming cells seemed to decrease slightly in all patients after the injection, followed by a normalization at 24-48 hours.
在首次注射人白细胞干扰素（IF）之前及之后的不同时间，对五名肿瘤患者外周淋巴细胞的自发细胞毒性进行了测定。其中四名患者的淋巴细胞在注射IF之前就表现出细胞毒性。注射IF后，细胞毒性最初下降，随后升高至注射前水平的1.5至5倍，在12小时达到峰值。此后，自发细胞毒性下降，但通常在注射后24小时内仍保持升高。第五名患者的淋巴细胞在注射IF之前自发细胞毒性非常低，注射后也没有明显变化。注射后，所有患者中E玫瑰花结形成细胞的比例似乎略有下降，随后在24至48小时恢复正常。
