UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA.
Analyst. 2017 May 2;142(9):1429-1433. doi: 10.1039/c7an00076f.
Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-C,D]diethylmalonic acid, which exhibits a large pH-dependent C chemical shift over the physiological range. We demonstrate that co-polarization with [1-C,D]tert-butanol accurately measures pH viaC NMR and magnetic resonance spectroscopic imaging in phantoms.
成像肿瘤 pH 值有助于表征侵袭性、转移性和治疗反应。我们报告了[2-C,D]二乙基丙二酸的高极化发展，其在生理范围内表现出与 pH 值密切相关的 C 化学位移。我们证明，通过 C NMR 和磁共振波谱成像在体模中与[1-C,D]叔丁醇的共极化可以准确测量 pH 值。
