Akça Mustafa, Ata Alper, Nayır Erdinç, Erdoğdu Süleyman, Arıcan Ali
Department of Internal Medicine, Mersin University, Faculty of Medicine, Mersin, Turkey.
Clinic of Medical Oncology, Mersin State Hospital, Mersin, Turkey.
J Breast Health. 2014 Oct 1;10(4):222-228. doi: 10.5152/tjbh.2014.1919. eCollection 2014 Oct.
Breast cancer can lead to alterations in quality of life of the patients. The aim of this study is to evaluate the changes in quality of life of the female patients who had undergone surgical treatment for breast cancer.
A total of 250 female patients (breast-preserving surgery (BPS), n=27, 11%; modified radical mastectomy (MRM), n=194, 77%, and simple mastectomy (SM), n=29; 11%) aged between 28-55 years (47.4±6.4 yrs) were included in the study. Patient information, demographic characteristics, income, and treatment modalities applied were recorded. Validated Turkish versions of EORTC QLQ-C30, and EORTC-BR23 questionnaires were used for all patients.
Breast-preserving surgery has a more favorable impact on general well-being, physical role, cognitive, psychological, and social functions, and symptom scale scores. When the identical parameters were taken into consideration, relatively favorable outcomes of BPS on the patients were observed relative to mastectomized patients. Besides, though not statistically significant, BPS has more patient-friendly effects on sexual function and sexual satisfaction in comparison with mastectomy. Patients with advanced stage disease and elder patients had more unfavorable health related quality of life (HRQoL) scores than younger patients, and those in their early stages of breast cancer.
Quality of life of BPS patients is less adversely affected relative to mastectomized patients. In the decision-making process, quality of life should be taken into consideration.
乳腺癌会导致患者生活质量发生改变。本研究旨在评估接受乳腺癌手术治疗的女性患者生活质量的变化。
本研究纳入了250例年龄在28 - 55岁(47.4±6.4岁)之间的女性患者,其中保乳手术(BPS)27例(11%),改良根治术(MRM)194例(77%),单纯乳房切除术(SM)29例(11%)。记录患者信息、人口统计学特征、收入及所采用的治疗方式。所有患者均使用经过验证的土耳其语版欧洲癌症研究与治疗组织核心生活质量问卷(EORTC QLQ - C30)和欧洲癌症研究与治疗组织乳腺癌特异性问卷(EORTC - BR23)。
保乳手术对总体健康状况、身体功能、认知、心理和社会功能以及症状量表评分有更有利的影响。在考虑相同参数时,相对于接受乳房切除术的患者,观察到保乳手术对患者有相对更有利的结果。此外,尽管无统计学意义,但与乳房切除术相比,保乳手术对性功能和性满意度有更有利于患者的影响。晚期疾病患者和老年患者的健康相关生活质量(HRQoL)评分比年轻患者以及乳腺癌早期患者更差。
相对于接受乳房切除术的患者,保乳手术患者的生活质量受到的不利影响较小。在决策过程中,应考虑生活质量。