一例采用过继性T细胞免疫疗法和放射疗法联合治疗局部及腹膜复发胃癌的远隔效应。
An abscopal effect in a case of concomitant treatment of locally and peritoneally recurrent gastric cancer using adoptive T-cell immunotherapy and radiotherapy.
作者信息
Sato Hiro, Suzuki Yoshiyuki, Yoshimoto Yuya, Noda Shin-Ei, Murata Kazutoshi, Takakusagi Yosuke, Okazaki Atsushi, Sekihara Tetsuo, Nakano Takashi
机构信息
Department of Radiation Oncology Gunma University Graduate School of Medicine Maebashi Japan.
Department of Radiation Oncology Fukushima Medical University Fukushima Japan.
出版信息
Clin Case Rep. 2017 Feb 15;5(4):380-384. doi: 10.1002/ccr3.758. eCollection 2017 Apr.
The mechanism of abscopal effect is becoming clear by the progress of cancer immunology. A 54-year-old male with recurrent gastric cancer presented an abscopal effect after radiotherapy with concurrent adoptive T-cell immunotherapy (immunoradiotherapy). Immunoradiotherapy has potential to induce abscopal effect by strengthening systemic antitumor immunity even in recurrent cancer.
随着癌症免疫学的进展，远隔效应的机制正逐渐明晰。一名54岁复发性胃癌男性患者在接受放疗联合过继性T细胞免疫治疗（免疫放疗）后出现了远隔效应。即使对于复发性癌症，免疫放疗也有通过增强全身抗肿瘤免疫力来诱导远隔效应的潜力。
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