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利用磁粒子成像在体内直接观察超顺磁性氧化铁纳米颗粒

Seeing SPIOs Directly In Vivo with Magnetic Particle Imaging.

作者信息

Zheng Bo, Yu Elaine, Orendorff Ryan, Lu Kuan, Konkle Justin J, Tay Zhi Wei, Hensley Daniel, Zhou Xinyi Y, Chandrasekharan Prashant, Saritas Emine U, Goodwill Patrick W, Hazle John D, Conolly Steven M

机构信息

Department of Bioengineering, UC Berkeley, Berkeley, CA, USA.

Triple Ring Technologies, Newark, CA, USA.

出版信息

Mol Imaging Biol. 2017 Jun;19(3):385-390. doi: 10.1007/s11307-017-1081-y.

Abstract

Magnetic particle imaging (MPI) is a new molecular imaging technique that directly images superparamagnetic tracers with high image contrast and sensitivity approaching nuclear medicine techniques-but without ionizing radiation. Since its inception, the MPI research field has quickly progressed in imaging theory, hardware, tracer design, and biomedical applications. Here, we describe the history and field of MPI, outline pressing challenges to MPI technology and clinical translation, highlight unique applications in MPI, and describe the role of the WMIS MPI Interest Group in collaboratively advancing MPI as a molecular imaging technique. We invite interested investigators to join the MPI Interest Group and contribute new insights and innovations to the MPI field.

摘要

磁粒子成像(MPI)是一种新型分子成像技术,它能够直接对超顺磁性示踪剂进行成像,具有高图像对比度和接近核医学技术的灵敏度,而且无需电离辐射。自诞生以来,MPI研究领域在成像理论、硬件、示踪剂设计和生物医学应用方面迅速取得进展。在此,我们阐述MPI的历史和领域,概述MPI技术及临床转化面临的紧迫挑战,突出MPI的独特应用,并描述世界分子影像学会(WMIS)MPI兴趣小组在协同推进MPI作为一种分子成像技术方面所发挥的作用。我们邀请感兴趣的研究人员加入MPI兴趣小组,为MPI领域贡献新见解和创新成果。

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